Gut microbiota and age-related macular degeneration: A growing partnership

Autores da FMUP

• Manuel Alberto De Almeida E Sousa Falcão

  Autor

• Angela Maria Veloso Guimarães Carneiro

  Autor

Participantes de fora da FMUP

• Lima-Fontes, M
• Meira, L
• Barata, P

Unidades de investigação

• Cirurgia e Fisiologia

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Age-related macular degeneration (AMD) is a leading cause of severe, irreversible vision impairment in developed countries, and its prevalence is rising all over the world, increasing sharply with age. AMD represents an acquired degeneration of the retina that causes significant central visual impairment through a combination of noneovascular and neovascular derangement. The main risk factors for the development of advanced AMD are increasing age, genetic factors, and cigarette smoking; however, the exact pathophysiology of AMD is yet relatively poorly understood. In recent years, the gut microbiota has been intensively studied and linked to several pathologic processes, including ocular diseases. In this sense, the aim of this review is to gather published evidence about the relationship between gut microbiota and AMD. (c) 2021 Elsevier Inc. All rights reserved.

Keywords

• Age-related macular degeneration; Gut microbiota; Nutrition; Gut dysbiosis; Gut-retina axis