Late Recurrence of Pancreatic Solid Pseudopapillary Neoplasm With Peritoneal Carcinomatosis Treated With Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Case Report

Data de publicação: 01/01/2022

Autores da FMUP

• Andreia Filipa Gomes Da Costa

  Autor

• Hugo Miguel Teixeira Ferraz Santos Sousa

  Autor

• Laura Elisabete Ribeiro Barbosa

  Autor

Participantes de fora da FMUP

• Nogueiro, J.
• Pacheco, J
• Meireles, S
• Melo, RB
• Aral, M

Unidades de investigação

• Cirurgia e Fisiologia

• Neurociências Clínicas e Saúde Mental

Abstract

Pancreatic solid pseudopapillary neoplasm (SPN) is a rare malignant tumour predominantly affecting young women. The occurrence of peritoneal carcinomatosis (PC) in this setting is an even rarer condition, usually related to perioperative tumour rupture. We present a case of a 43-year-old woman who previously underwent distal splenopancreatectomy after the diagnosis of a pancreatic SPN. Thirteen years later, the patient underwent a radical hysterectomy due to a uterine myoma. Intraoperatively, a peritoneal mass was additionally found and resected. Histological examination revealed an implant with morphology compatible with pancreatic SPN. The patient was then referred to our institution. Staging MRI and CT revealed multiple nodular lesions adjacent to the left colon, suggestive of peritoneal implants. The patient was then submitted to cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin and irinotecan. Histological examination confirmed peritoneal involvement by a pancreatic SPN. The postoperative course was unremarkable. Two years after surgery, the patient remains asymptomatic with no evidence of relapse. Despite SPN being cancer with a relatively indolent evolution, one needs to be aware of a possible recurrence several years after the primary resection, mainly in patients with evidence of intraoperative tumour rupture.

Keywords

• late recurrence; peritoneal metastasis; hyperthermic intraperitoneal chemotherapy; cytoreduction surgical procedures; pancreatic neoplasms