The Emerging Role of MicroRNAs and Other Non-Coding RNAs in Cancer Cachexia

Autores da FMUP
Participantes de fora da FMUP
- Santos, JMO
- Da Silva, SP
- da Costa, RMG
Abstract
Cancer cachexia or wasting is a paraneoplastic syndrome characterized by systemic inflammation and an involuntary loss of body mass that cannot be reversed by normal nutritional support. This syndrome affects 50%-80% of cancer patients, depending on the tumor type and patient characteristics, and it is responsible for up to 20% of cancer deaths. MicroRNAs are a class of non-coding RNAs (ncRNAs) with 19 to 24 nucleotides in length of which the function is to regulate gene expression. In the last years, microRNAs and other ncRNAs have been demonstrated to have a crucial role in the pathogenesis of several diseases and clinical potential. Recently, ncRNAs have begun to be associated with cancer cachexia by modulating essential functions like the turnover of skeletal muscle and adipose tissue. Additionally, circulating microRNAs have been suggested as potential biomarkers for patients at risk of developing cancer cachexia. In this review article, we present recent data concerning the role of microRNAs and other ncRNAs in cancer cachexia pathogenesis and their possible clinical relevance.
Dados da publicação
- ISSN/ISSNe:
- 2072-6694, 2072-6694
- Tipo:
- Review
- Páginas:
- -
Cancers Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 29
Documentos
- Não há documentos
Filiações
Keywords
- cancer cachexia; muscle wasting; adipose tissue wasting; ncRNAs; microRNAs; lncRNAs; circRNAs; biomarkers; therapeutic targets
Financiamento
Proyectos asociados
Previsão das readmissões dos doentes à Urgência Pediátrica: aplicação das técnicas de aprendizagem supervisionadas.
Investigador Principal: Rui Manuel de Medeiros Melo Silva
Estudo Observacional Académico (UrgPediatr) . 2019
Characterization of Pain and Genetic Variants Associated with Pain in Patients with Metastatic Bone Disease
Investigador Principal: Rui Manuel de Medeiros Melo Silva
Estudo Clínico Académico . 2019
Citar a publicação
Santos J,Da SP,da RMG,Medeiros R. The Emerging Role of MicroRNAs and Other Non-Coding RNAs in Cancer Cachexia. Cancers. 2020. 12(4):1004. IF:6,639. (1).