Portal de investigação
Visceral Dissemination of Mucocutaneous Leishmaniasis in a Kidney Transplant Recipient
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Marques, N
- Bustorff, M
- Da Silva, AC
- Pinto, AI
- Santarém, N
- Ferreira, F
- Nunes, A
- Cerqueira, A
- Rocha, A
- Santos, J
- Moura, C
- Cerejeira, A
- Vide, J
- Cancela, J
- Simoes, JS
Unidades de investigação
Abstract
Intracellular protozoan of the genus Leishmania, endemic in the Mediterranean basin, are the cause of cutaneous (CL), mucocutaneous (MCL), and visceral leishmaniasis (VL). A 75-year-old woman was admitted nine years after a second kidney transplant (KT), due to persistent pancytopenia and fever. She presented edema and erythema of the nose in the last two years and an exophytic nodular lesion located on the left arm, with areas of peripheral necrosis and central ulceration in the last 18 months. A bone marrow biopsy revealed features compatible with Leishmania amastigotes, and polymerase chain reaction test (PCR) for Leishmania infantum was positive. Moreover, biopsy and PCR for L. infantum of the cutaneous lesion on the patient's left arm and nose and PCR from peripheral blood were positive. Thus, a diagnosis of CL, MCL, and VL was made, and liposomal amphotericin B was initiated, but the patient had an unfavorable outcome and died. This is the first report of a KT recipient presenting with the entire spectrum of leishmaniasis. In Portugal, this infection is rare-so a high degree of clinical suspicion is required for its diagnosis, especially in endemic regions, as visceral leishmaniasis is a potentially life-threatening infection.
Dados da publicação
- ISSN/ISSNe:
- 2076-0817, 2076-0817
- Tipo:
- Article
- Páginas:
- 1-11
- Link para outro recurso:
- www.scopus.com
Pathogens MDPI AG
Citações Recebidas na Web of Science: 4
Citações Recebidas na Scopus: 5
Documentos
- Não há documentos
Filiações
Keywords
- leishmaniasis; transplant; immunosuppression
Proyectos asociados
: C3 glomerulonephritis associated with monoclonal gammopathy of renal significance
Investigador Principal: Inês Passos e Castro Neto Ferreira
Estudo Clínico Académico (Glomerulonephritis) . 2020
Risk evaluation of metformin use in patients with kidney injury.
Investigador Principal: Susana Maria Moreira Sampaio Norton
Estudo Clínico Académico (Metformin) . 2020
New insights into immune mechanisms in idiopathic membranous nephropathy
Investigador Principal: Inês Passos e Castro Neto Ferreira
Estudo Clínico Académico (idiopathic) . 2020
Citar a publicação
Marques N,Bustorff M,Da AC,Pinto AI,Santarém N,Ferreira F,Nunes A,Cerqueira A,Rocha A,Ferreira I,Tavares I,Santos J,Fonseca E,Moura C,Cerejeira A,Vide J,Cancela J,Simoes JS,Sampaio S. Visceral Dissemination of Mucocutaneous Leishmaniasis in a Kidney Transplant Recipient. Pathogens. 2021. 10. (1):p. 1-11. IF:4,531. (2).
