Visceral Dissemination of Mucocutaneous Leishmaniasis in a Kidney Transplant Recipient

Data de publicação:

Autores da FMUP

  • Inês Passos E Castro Neto Ferreira

    Autor

  • Isabel Cristina Pinho Tavares Salomé

    Autor

  • Elsa Maria Pereira Da Fonseca

    Autor

  • Susana Maria Moreira Sampaio Norton

    Autor

Participantes de fora da FMUP

  • Marques, N
  • Bustorff, M
  • Da Silva, AC
  • Pinto, AI
  • Santarém, N
  • Ferreira, F
  • Nunes, A
  • Cerqueira, A
  • Rocha, A
  • Santos, J
  • Moura, C
  • Cerejeira, A
  • Vide, J
  • Cancela, J
  • Simoes, JS

Unidades de investigação

Abstract

Intracellular protozoan of the genus Leishmania, endemic in the Mediterranean basin, are the cause of cutaneous (CL), mucocutaneous (MCL), and visceral leishmaniasis (VL). A 75-year-old woman was admitted nine years after a second kidney transplant (KT), due to persistent pancytopenia and fever. She presented edema and erythema of the nose in the last two years and an exophytic nodular lesion located on the left arm, with areas of peripheral necrosis and central ulceration in the last 18 months. A bone marrow biopsy revealed features compatible with Leishmania amastigotes, and polymerase chain reaction test (PCR) for Leishmania infantum was positive. Moreover, biopsy and PCR for L. infantum of the cutaneous lesion on the patient's left arm and nose and PCR from peripheral blood were positive. Thus, a diagnosis of CL, MCL, and VL was made, and liposomal amphotericin B was initiated, but the patient had an unfavorable outcome and died. This is the first report of a KT recipient presenting with the entire spectrum of leishmaniasis. In Portugal, this infection is rare-so a high degree of clinical suspicion is required for its diagnosis, especially in endemic regions, as visceral leishmaniasis is a potentially life-threatening infection.

Dados da publicação

ISSN/ISSNe:
2076-0817, 2076-0817

Pathogens  MDPI AG

Tipo:
Article
Páginas:
1-11
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 4

Citações Recebidas na Scopus: 5

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Keywords

  • leishmaniasis; transplant; immunosuppression

Proyectos asociados

: C3 glomerulonephritis associated with monoclonal gammopathy of renal significance

Investigador Principal: Inês Passos e Castro Neto Ferreira

Estudo Clínico Académico (Glomerulonephritis) . 2020

Risk evaluation of metformin use in patients with kidney injury.

Investigador Principal: Susana Maria Moreira Sampaio Norton

Estudo Clínico Académico (Metformin) . 2020

New insights into immune mechanisms in idiopathic membranous nephropathy

Investigador Principal: Inês Passos e Castro Neto Ferreira

Estudo Clínico Académico (idiopathic) . 2020

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