Portal de investigação
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Buetti, N
- Tabah, A
- Loiodice, A
- Ruckly, S
- Aslan, AT
- Montrucchio, G
- Cortegiani, A
- Saltoglu, N
- Kayaaslan, B
- Aksoy, F
- Murat, A
- Akdogan, Ö
- Saracoglu, KT
- Erdogan, C
- Leone, M
- Ferrer, R
- Hayashi, Y
- Ramanan, M
- Morris, AC
- Barbier, F
- Timsit, JF
- Eurobact 2 Study Grp
Unidades de investigação
Abstract
Background: The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods: We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients' characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results: A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49-2.45). Conclusions: We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality.
Dados da publicação
- ISSN/ISSNe:
- 1466-609X, 1364-8535
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Critical Care BioMed Central Ltd.
Citações Recebidas na Web of Science: 23
Citações Recebidas na Scopus: 32
Documentos
- Não há documentos
Filiações
Keywords
- Bloodstream infection; ICU-acquired; COVID-19; Enterococcus; Bacteremia
Financiamento
Proyectos asociados
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Investigador Principal: José Artur Osório de Carvalho Paiva
Estudo Clínico Académico . 2022
Citar a publicação
Buetti N,Tabah A,Loiodice A,Ruckly S,Aslan AT,Montrucchio G,Cortegiani A,Saltoglu N,Kayaaslan B,Aksoy F,Murat A,Akdogan Ö,Saracoglu KT,Erdogan C,Leone M,Ferrer R,Paiva JA,Hayashi Y,Ramanan M,Morris AC,Barbier F,Timsit JF,Eurobact 2GRP. Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study. Crit. Care. 2022. 26. (1):319. IF:15,100. (1).
