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  3. Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study

Data de publicação:

Autores da FMUP

  • José Artur Osório De Carvalho Paiva

    Autor

Participantes de fora da FMUP

  • Buetti, N
  • Tabah, A
  • Loiodice, A
  • Ruckly, S
  • Aslan, AT
  • Montrucchio, G
  • Cortegiani, A
  • Saltoglu, N
  • Kayaaslan, B
  • Aksoy, F
  • Murat, A
  • Akdogan, Ö
  • Saracoglu, KT
  • Erdogan, C
  • Leone, M
  • Ferrer, R
  • Hayashi, Y
  • Ramanan, M
  • Morris, AC
  • Barbier, F
  • Timsit, JF
  • Eurobact 2 Study Grp

Unidades de investigação

Abstract

Background: The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods: We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients' characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results: A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49-2.45). Conclusions: We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality.

Dados da publicação

ISSN/ISSNe:
1466-609X, 1364-8535

Critical Care  BioMed Central Ltd.

Tipo:
Article
Páginas:
-
PubMed:
36258239
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 23

Citações Recebidas na Scopus: 32

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Keywords

  • Bloodstream infection; ICU-acquired; COVID-19; Enterococcus; Bacteremia

Financiamento

European Society of Clinical Microbiology and Infectious Diseases (ESCMID) study Group for Infections in Critically Ill Patients
European society of Intensive Care Medicine
MRC (MR/V006118/1)
Norva Dahlia foundation
Redcliffe Hospital Private Practice Trust Fund
Swiss National Science Foundation (P4P4PM_194449)
Swiss National Science Foundation (P4P4PM_194449)

Projetos associados

The impact of the Covid-19 pandemic on antimicrobial consumption: a descriptive and correlation analysis in a tertiary care hospital in Portugal

Investigador Principal: José Artur Osório de Carvalho Paiva

Estudo Clínico Académico (Antimicrobial consumpti) . 2021

Severe community-acquired pneumonia: from severity assessment to outcome.

Investigador Principal: José Artur Osório de Carvalho Paiva

Estudo Clínico Académico . 2022

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