Portal de investigação
Bone and Cytokine Markers Associated With Bone Disease in Systemic Mastocytosis
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Henriques, AF
- Matito, A
- Jara-Acevedo, M
- Caldas, C
- Mayado, A
- Muñoz-González, JI
- Cavaleiro-Rufo, J
- García-Montero, A
- Orfao, A
- Sanchez-Munoz, L
- álvarez-Twose, I
Unidades de investigação
Abstract
BACKGROUND: Mastocytosis encompasses a heterogeneous group of diseases characterized by tissue accumulation of clonal mast cells, which frequently includes bone involvement. Several cytokines have been shown to play a role in the pathogenesis of bone mass loss in systemic mastocytosis (SM), but their role in SM-associated osteosclerosis remains unknown.OBJECTIVE: To investigate the potential association between cytokine and bone remodeling markers with bone disease in SM, aiming at identifying biomarker profiles associated with bone loss and/or osteosclerosis.METHODS: A total of 120 adult patients with SM, divided into 3 age and sex-matched groups according to their bone status were studied: (1) healthy bone (n = 46), (2) significant bone loss (n = 47), and (3) diffuse bone sclerosis (n = 27). Plasma levels of cytokines and serum baseline tryptase and bone turnover marker levels were measured at diagnosis.RESULTS: Bone loss was associated with significantly higher levels of serum baseline tryptase (P = .01), IFN-g (P = .05), IL-1b (P = .05), and IL-6 (P = .05) versus those found in patients with healthy bone. In contrast, patients with diffuse bone scle-rosis showed significantly higher levels of serum baseline tryp-tase (P < .001), C-terminal telopeptide (P < .001), amino-terminal propeptide of type I procollagen (P < .001), osteocalcin (P < .001), bone alkaline phosphatase (P < .001), osteopontin (P < .01), and the C-C Motif Chemokine Ligand 5/RANTES chemokine (P = .01), together with lower IFN-g (P = .03) and RANK-ligand (P = .04) plasma levels versus healthy bone cases.CONCLUSIONS: SM with bone mass loss is associated with a proinflammatory cytokine profile in plasma, whereas diffuse bone sclerosis shows increased serum/plasma levels of biomarkers related to bone formation and turnover, in association with an immunosuppressive cytokine secretion profile. (c) 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). (J Allergy Clin Immunol Pract 2023;11:1536-47)
Dados da publicação
- ISSN/ISSNe:
- 2213-2198, 2213-2201
- Tipo:
- Article
- Páginas:
- 1536-1547
- Link para outro recurso:
- www.scopus.com
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE Elsevier
Citações Recebidas na Web of Science: 4
Citações Recebidas na Scopus: 4
Documentos
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Filiações
Keywords
- Systemic mastocytosis; Cytokines; Biomarkers; Bone metabolism; Osteoporosis; Osteosclerosis; Bone disease
Campos de estudo
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Citar a publicação
Rama TA,Henriques AF,Matito A,Jara M,Caldas C,Mayado A,Muñoz JI,Moreira A,Cavaleiro J,García A,Orfao A,Sanchez L,álvarez I. Bone and Cytokine Markers Associated With Bone Disease in Systemic Mastocytosis. J. Allergy Clin. Immunol. Pract. 2023. 11. (5):p. 1536-1547. IF:9,400. (1).
