Portal de investigação
Definition of mild to moderate ulcerative colitis in clinical trials: A systematic literature review
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Caron, B
- Jairath, V
- D'Amico, F
- Paridaens, K
- Danese, S
- Peyrin-Biroulet, L
Unidades de investigação
Abstract
We performed a systematic review to investigate the definition of mild to moderate active ulcerative colitis (UC), and to describe predictors of good response to treatment in clinical trials assessing 5-ASA and/or budesonide. Thirty-nine randomized controlled trials were included. The UC Disease Activity Index (UCDAI) was the most frequent score used for defining mild to moderate active UC (16 studies, 41%), followed by Clinical Activity Index in 11 studies (28.2%). Four different cut-offs were used to define mild to moderate active UC using the UCDAI. The most frequently reported predictors of good response to treatment was a mild and moderate disease activity. There is heterogeneity in the definition of mild to moderate active UC in randomized clinical trials. A standardized definition of mild to moderate active UC used for inclusion of patients in clinical trials is needed.
Dados da publicação
- ISSN/ISSNe:
- 2050-6406, 2050-6414
- Tipo:
- Review
- Páginas:
- 854-867
- DOI:
- 10.1002/ueg2.12283
- Link para outro recurso:
- www.scopus.com
United European Gastroenterology Journal John Wiley & Sons Inc.
Citações Recebidas na Web of Science: 6
Citações Recebidas na Scopus: 11
Documentos
- Não há documentos
Filiações
Keywords
- definition; mild; moderate; predictive factor; ulcerative colitis
Financiamento
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Citar a publicação
Caron B,Jairath V,D'Amico F,Paridaens K,Magro F,Danese S,Peyrin L. Definition of mild to moderate ulcerative colitis in clinical trials: A systematic literature review. United Eur. Gastroenterol. J. 2022. 10(8):p. 854-867. IF:6,000. (1).
