Chronic metformin intake and gastric cancer: A pooled analysis within the Stomach cancer Pooling (StoP) Project
Autores da FMUP
Participantes de fora da FMUP
- Sassano, M
- Mariani, M
- Pelucchi, C
- Vicente, M
- Pinto-Carbó, M
- Morais, S
- La Vecchia, C
- Pastorino, R
- Boccia, S
Unidades de investigação
Abstract
Introduction: The association between chronic use of metformin and risk of gastric cancer (GC) has been inves-tigated with contradicting results. We aimed to study the association between chronic use of metformin and GC by using data from the Stomach cancer Pooling (StoP) Project, an epidemiological consortium of case-control studies on GC. Methods: Data from three studies of the StoP Project with available information on metformin intake were analyzed. Multivariable logistic regression models were used to estimate study-specific odds ratios (ORs) and 95% confi-dence intervals (CIs) for the association between chronic use of metformin and GC risk. Analyses were adjusted for sex, age, socioeconomic status, body mass index, smoking status, alcohol drinking status, and history of diabetes. Study-specific ORs and 95% CIs were then pooled with a random-effects model. The dose-response relationship between the duration of metformin intake and GC was assessed with a one-stage logistic model, and the duration of intake was modelled using second-order fractional polynomials. Results: The OR of GC in metformin users versus non-users was 1.01 (95% CI=0.61, 1.67). The association be-tween metformin and GC did not change among different strata of study participants' characteristics or when restricting the analyses to those with a history of diabetes. The dose-response analysis showed a slightly reducing trend in the OR of GC and a borderline significant as-sociation with increasing duration of metformin intake. Conclusions: The results of our study do not clearly support an association between chronic use of metformin and GC, warranting further research.
Dados da publicação
- ISSN/ISSNe:
- 1877-7821, 1877-783X
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Cancer Epidemiology Elsevier BV
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 4
Documentos
- Não há documentos
Filiações
Keywords
- Gastric cancer; Stomach neoplasms; Metformin; Pooled analysis; Consortium
Campos de estudo
Financiamento
Proyectos asociados
Breast cancer heterogeneity - etiology, clinical management, use of health resources and survival
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2022
Longitudinal Assessment of Cognitive Decline in Breast and Prostate Cancer Survivors
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico (Cognitive Decline) . 2022
Healthcare use among cancer patients and their partners in different phases of the cancer pathway
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2021
Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2020
Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2020
RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2019
Citar a publicação
Sassano M,Mariani M,Pelucchi C,Vicente M,Pinto M,lunet N,Morais S,La Vecchia C,Pastorino R,Boccia S. Chronic metformin intake and gastric cancer: A pooled analysis within the Stomach cancer Pooling (StoP) Project. Cancer Epidemiol. 2022. 81. 102286. IF:2,600. (3).