Chronic metformin intake and gastric cancer: A pooled analysis within the Stomach cancer Pooling (StoP) Project

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Sassano, M
  • Mariani, M
  • Pelucchi, C
  • Vicente, M
  • Pinto-Carbó, M
  • Morais, S
  • La Vecchia, C
  • Pastorino, R
  • Boccia, S

Unidades de investigação

Abstract

Introduction: The association between chronic use of metformin and risk of gastric cancer (GC) has been inves-tigated with contradicting results. We aimed to study the association between chronic use of metformin and GC by using data from the Stomach cancer Pooling (StoP) Project, an epidemiological consortium of case-control studies on GC. Methods: Data from three studies of the StoP Project with available information on metformin intake were analyzed. Multivariable logistic regression models were used to estimate study-specific odds ratios (ORs) and 95% confi-dence intervals (CIs) for the association between chronic use of metformin and GC risk. Analyses were adjusted for sex, age, socioeconomic status, body mass index, smoking status, alcohol drinking status, and history of diabetes. Study-specific ORs and 95% CIs were then pooled with a random-effects model. The dose-response relationship between the duration of metformin intake and GC was assessed with a one-stage logistic model, and the duration of intake was modelled using second-order fractional polynomials. Results: The OR of GC in metformin users versus non-users was 1.01 (95% CI=0.61, 1.67). The association be-tween metformin and GC did not change among different strata of study participants' characteristics or when restricting the analyses to those with a history of diabetes. The dose-response analysis showed a slightly reducing trend in the OR of GC and a borderline significant as-sociation with increasing duration of metformin intake. Conclusions: The results of our study do not clearly support an association between chronic use of metformin and GC, warranting further research.

Dados da publicação

ISSN/ISSNe:
1877-7821, 1877-783X

Cancer Epidemiology  Elsevier BV

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 1

Citações Recebidas na Scopus: 4

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Keywords

  • Gastric cancer; Stomach neoplasms; Metformin; Pooled analysis; Consortium

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Financiamento

Proyectos asociados

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Estudo Clínico Académico (Cognitive Decline) . 2022

Healthcare use among cancer patients and their partners in different phases of the cancer pathway

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Estudo Clínico Académico . 2021

Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

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Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

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Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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