Portal de investigação
Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females: Implication of menopause and ageing
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Sousa, S
- Pestana, D
- Faria, G
- Delerue-Matos, C
- Domingues, VF
Abstract
Fatty acids (FA) are biomarkers of metabolic dysfunction. Adipose tissue is the largest reservoir of FA and acts differently in obese individuals. Menopause by itself significantly alters metabolism, lipid metabolism dysre-gulation, and adipose tissue distribution. How adipose tissue FA alters an obese individual's metabolism depending on a female's menopausal status is yet poorly understood.Hence, the subcutaneous (scAT) and visceral adipose tissue (vAT) FA profile for 173 obese premenopausal and postmenopausal women was measured and associated with biochemical parameters. scAT and vAT FA profiles were distinct by themselves and in menopause. In total 816 associations were found with biochemical param-eters, where only 58 were independent of the menopausal status.The associations found to emphasize the importance of assessing the adipose tissue FA profile and how their behavior changes with menopause. The FA are crucial in metabolic processes and can be helpful biomarkers in the prevention/treatment and follow-up of female obesity.
Dados da publicação
- ISSN/ISSNe:
- 0952-3278, 1532-2823
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Prostaglandins Leukotrienes and Essential Fatty Acids Churchill Livingstone
Documentos
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Filiações
Keywords
- Lipid; Biochemical parameters; Adipocytes; Obesity; Metabolism; Women
Financiamento
Proyectos asociados
Unraveling the Effects of Anthocyanins in Metabolic Health and Disease: Insights on Bioavailability and Gut Microbiota Modulation
Investigador Principal: Maria da Conceição Costa Pinho Calhau
Estudo Clínico Académico . 2019
Citar a publicação
Sousa S,Pestana D,Faria G,Delerue C,Calhau C,Domingues VF. Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese females: Implication of menopause and ageing. Prostaglandins Leukotrienes Essent. Fatty Acids. 2023. 195. 102581. IF:3,000. (3).
