Association of metabolic syndrome components and NAFLD with quality of life: Insights from a cross-sectional study

Autores da FMUP

• Joaquim Adelino Correia Ferreira Leite Moreira

  Autor

• Paula Isabel Marques Simões De Freitas

  Autor

Participantes de fora da FMUP

• Borges-Canha M.
• Leite A.R.
• Godinho T.
• Liberal R.
• Correia-Chaves J.
• Lourenço I.M.
• von Hafe M.
• Vale C.
• Fragão-Marques M.
• Pimentel-Nunes P.
• Carvalho D.
• Neves J.S.

Unidades de investigação

• Cirurgia e Fisiologia

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Medicina

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Aim: Metabolic syndrome (MetS) is associated with higher cardiovascular and metabolic risks, as well as with psychosocial disorders. Data regarding quality of life (QoL) in patients with MetS, point towards a significative association between MetS and a worse QoL. It remains unclear whether MetS components and non-alcoholic fatty liver disease (NAFLD) are associated with QoL in these individuals. We aimed to evaluate the association between QoL of patients with MetS and prespecified metabolic parameters (anthropometric, lipidic and glucose profiles), the risk of hepatic steatosis and fibrosis, and hepatic elastography parameters. Methods: Cross-sectional study including patients from microDHNA cohort. This cohort includes patients diagnosed with MetS, 18 to 75 years old, followed in our tertiary center. The evaluation included anamnesis, physical examination, a QoL questionnaire (Short-Form Health Survey, SF-36), blood sampling and hepatic elastography. We used ordered logistic regression models adjusted to sex, age and body mass index to evaluate the associations between the QoL domains evaluated by SF-36 and the prespecified parameters. Results: We included a total of 65 participants with MetS, with 54% being female and the mean age 61.9 ± 9.6 years old. A worse metabolic profile, specifically higher waist circumference, lower HDL, higher triglycerides, and more severe hepatic steatosis, were associated with worse QoL scores in several domains. We found no significant association of hepatic fibrosis with QoL. Conclusion: Our data suggests that there is a link between a worse metabolic profile (specifically poorer lipidic profile and presence of hepatic steatosis) and a worse QoL in patients with MetS. © 2024 Primary Care Diabetes Europe

Copyright © 2024 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

Keywords

• Adolescent; Adult; Aged; Cross-Sectional Studies; Female; Humans; Lipids; Male; Metabolic Syndrome; Middle Aged; Non-alcoholic Fatty Liver Disease; Quality of Life; Young Adult; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; lipid; adult; aged; anamnesis; anthropometry; Article; blood sampling; body mass; cholesterol blood level; clinical evaluation; clinical feature; cohort analysis; cross-sectional study; demographics; diabetes mellitus; diastolic blood pressure; disease association; elastography; fatty liver; female; human; lipid fingerprinting; liver cirrhosis; liver fibrosis; major clinical study; male; metabolic parameters; metabolic syndrome X; metabolome; nonalcoholic fatty liver; physical examination; primary medical care; quality of life; risk; Short Form 36; systolic blood pressure; tertiary care center; waist circumference; waist hip ratio; adolescent; complication; diagnostic imaging; metabolic syndrome X; metabolism; m