Corticotropin-releasing hormone and obesity: From fetal life to adulthood

Data de publicação: 01/01/2024 Data Ahead of Print: 03/05/2024

Autores da FMUP

Joaquim Adelino Correia Ferreira Leite Moreira

Autor

Participantes de fora da FMUP

Vasconcelos I.
von Hafe M.
Adão R.
Brás-Silva C.

Unidades de investigação

Cirurgia e Fisiologia
Laboratório Associado RISE- Rede de Investigação em Saúde

Investigador

Fernando Carlos De Landér Schmitt
RISE-Health

Investigador

Fernando Carlos De Landér Schmitt

Abstract

Obesity is among the most common chronic disorders, worldwide. It is a complex disease that reflects the interactions between environmental influences, multiple genetic allelic variants, and behavioral factors. Recent developments have also shown that biological conditions in utero play an important role in the programming of energy homeostasis systems and might have an impact on obesity and metabolic disease risk. The corticotropin-releasing hormone (CRH) family of neuropeptides, as a central element of energy homeostasis, has been evaluated for its role in the pathophysiology of obesity. This review aims to summarize the relevance and effects of the CRH family of peptides in the pathophysiology of obesity spanning from fetal life to adulthood. © 2024 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.

Dados da publicação

ISSN/ISSNe:: 1467-789X, 1467-7881
Tipo:: Review
Páginas:: -
DOI:: 10.1111/obr.13763
Link para outro recurso:: www.scopus.com

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Métricas

Filiações

Vasconcelos I.:: Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal
von Hafe M.:: Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal
Adão R.:: Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal

Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain

CIBER Enfermedades Respiratorias (Ciberes), Madrid, Spain
Leite-Moreira A.:: Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal
Brás-Silva C.:: Cardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal

Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal

Keywords

Adult; Corticotropin-Releasing Hormone; Energy Metabolism; Female; Homeostasis; Humans; Obesity; Pregnancy; Prenatal Exposure Delayed Effects; corticotropin; corticotropin releasing factor; proopiomelanocortin; urocortin; corticotropin releasing factor; adulthood; childhood; feeding behavior; fetus development; human; nonhuman; obesity; physical activity; Review; adult; energy metabolism; female; homeostasis; metabolism; physiology; pregnancy; prenatal exposure delayed effect