Portal de investigação
Exercise preconditioning prevents left ventricular dysfunction and remodeling in monocrotaline-induced pulmonary hypertension.
Autores da FMUP
Participantes de fora da FMUP
- Schmidt C
- Bovolini JA
- Gonçalves N
- Vasques-Nóvoa F
- Andrade MDA
- Santos M
- Henriques-Coelho T
- Duarte JA
- Moreira-Gonçalves D
Unidades de investigação
Abstract
BACKGROUND: Despite pulmonary arterial hypertension (PAH) directly affects the right ventricle (RV), important structural, functional, and molecular changes also occur in left ventricle (LV). The objective of our study was to analyze the hypothetical cardioprotective effects of exercise preconditioning on LV in rats with monocrotaline (MCT)-induced PAH. METHODS: Forty male Wistar rats were randomly separated in sedentary (SED) and trained group (EX; running sessions of 60 min/day, 5 days/wk, at 25 m/min, for 4 weeks). After 4 weeks, animals were injected with MCT (60 mg/kg; SED + MCT; EX + MCT) or vehicle (SED + V). Following an additional period of 4 weeks where all animals remained sedentary, we completed LV hemodynamic evaluation in baseline and isovolumic conditions and collected LV samples for histological and molecular analysis. RESULTS: Preconditioning with exercise was capable to restore LV systolic and diastolic dysfunction in both baseline and isovolumic conditions (P < .05). This improved was paralleled with prevention of LV cardiomyocytes atrophy, fibrosis, and endothelin 1 mRNA levels (P < .05). CONCLUSIONS: Our findings suggest that exercise preconditioning can prevent LV dysfunction secondary to MCT-induced PAH, which is of particular interest for the familial form of the disease that is manifested by greater severity or earlier onset.
Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of PBJ-Associação Porto Biomedical/Porto Biomedical Society. All rights reserved.
Dados da publicação
- ISSN/ISSNe:
- 2444-8664, 2444-8672
- Tipo:
- Article
- Páginas:
- -
Porto Biomedical Journal Elsevier Espana
Documentos
- Não há documentos
Filiações
Keywords
- cardioprotection; exercise training; pulmonary arterial hypertension
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Citar a publicação
Schmidt C,Bovolini JA,Gonçalves N,Vasques F,Andrade M,Santos M,Leite A,Henriques T,Duarte JA,Moreira D. Exercise preconditioning prevents left ventricular dysfunction and remodeling in monocrotaline-induced pulmonary hypertension. Porto Biomed. J. 2020. 5. (5):e081.
