Exercise preconditioning prevents left ventricular dysfunction and remodeling in monocrotaline-induced pulmonary hypertension.

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Joaquim Adelino Correia Ferreira Leite Moreira

    Autor

Participantes de fora da FMUP

  • Schmidt C
  • Bovolini JA
  • Gonçalves N
  • Vasques-Nóvoa F
  • Andrade MDA
  • Santos M
  • Henriques-Coelho T
  • Duarte JA
  • Moreira-Gonçalves D

Unidades de investigação

Abstract

BACKGROUND: Despite pulmonary arterial hypertension (PAH) directly affects the right ventricle (RV), important structural, functional, and molecular changes also occur in left ventricle (LV). The objective of our study was to analyze the hypothetical cardioprotective effects of exercise preconditioning on LV in rats with monocrotaline (MCT)-induced PAH. METHODS: Forty male Wistar rats were randomly separated in sedentary (SED) and trained group (EX; running sessions of 60 min/day, 5 days/wk, at 25 m/min, for 4 weeks). After 4 weeks, animals were injected with MCT (60 mg/kg; SED + MCT; EX + MCT) or vehicle (SED + V). Following an additional period of 4 weeks where all animals remained sedentary, we completed LV hemodynamic evaluation in baseline and isovolumic conditions and collected LV samples for histological and molecular analysis. RESULTS: Preconditioning with exercise was capable to restore LV systolic and diastolic dysfunction in both baseline and isovolumic conditions (P < .05). This improved was paralleled with prevention of LV cardiomyocytes atrophy, fibrosis, and endothelin 1 mRNA levels (P < .05). CONCLUSIONS: Our findings suggest that exercise preconditioning can prevent LV dysfunction secondary to MCT-induced PAH, which is of particular interest for the familial form of the disease that is manifested by greater severity or earlier onset.

Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of PBJ-Associação Porto Biomedical/Porto Biomedical Society. All rights reserved.

Dados da publicação

ISSN/ISSNe:
2444-8664, 2444-8672

Porto Biomedical Journal  Elsevier Espana

Tipo:
Article
Páginas:
-

Documentos

  • Não há documentos

Filiações mostrar / ocultar

Keywords

  • cardioprotection; exercise training; pulmonary arterial hypertension

Proyectos asociados

Estudo do tratamento da doença valvular aórtica.

Investigador Principal: Joaquim Adelino Correia Ferreira Leite Moreira

Estudo Observacional Académico (AORTA) . UniC . 2019

Eficácia da transposição de um pedículo adiposo pericárdico sobre o enfarte de miocárdio em pacientes (ensaio AGTP II)

Investigador Principal: Joaquim Adelino Correia Ferreira Leite Moreira

Ensaio Clínico Académico (Ensaio AGTP II) . 2019

Early Dual Antiplatelet Therapy versus Aspirin Monotherapy after Coronary Artery Bypass Surgery: survival and safety outcomes

Investigador Principal: Joaquim Adelino Correia Ferreira Leite Moreira

Estudo Clínico Académico (Bypass) . 2020

Early and Midterm Outcomes following Aortic Valve Replacement with Mechanical versus Bioprosthetic Valves in Patients aged 50 to 70 Years

Investigador Principal: Joaquim Adelino Correia Ferreira Leite Moreira

Estudo Clínico Académico (Aortic Valve Replacemen) . 2020

Impacto clínico e hemodinâmico da substituição cirúrgica da válvula aórtica por biopróteses de última geração

Investigador Principal: Joaquim Adelino Correia Ferreira Leite Moreira

Estudo Clínico Académico . 2020

Condicionamento isquémico cardíaco remoto como adjuvante da revascularização miocárdia na doença coronário aguda

Investigador Principal: Joaquim Adelino Correia Ferreira Leite Moreira

Estudo Clínico Académico . 2020

Citar a publicação

Partilhar a publicação