Salt-inducible kinases: new players in pulmonary arterial hypertension?

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Patrício Manuel Vieira Araújo Soares Da Silva

    Autor

  • António Pedro De Barros Gomes

    Autor

Participantes de fora da FMUP

  • Antonio, Tatiana
  • Pires, Nuno M.

Unidades de investigação

Abstract

Salt-inducible kinases (SIKs) are serine/threonine kinases belonging to the AMP -activated protein kinase (AMPK) family. Accumulating evidence indicates that SIKs phosphorylate multiple targets, including histone deacetylases (HDACs) and cAMP response element-binding protein (CREB)-regulated transcriptional coactivators (CRTCs), to coordinate signaling pathways implicated in metabolism, cell growth, proliferation, apoptosis, and inflammation. These pathways down-stream of SIKs are altered not only in pathologies like cancer, systemic hyperten-sion, and inflammatory diseases, but also in pulmonary arterial hypertension (PAH), a multifactorial disease characterized by pulmonary vasoconstriction, inflammation and remodeling of pulmonary arteries owing to endothelial dysfunc-tion and aberrant proliferation of smooth muscle cells (SMCs). In this opinion arti-cle, we present evidence of SIKs as modulators of key signaling pathways involved in PAH pathophysiology and discuss the potential of SIKs as therapeutic targets for PAH, emphasizing the need for deeper molecular insights on PAH.

Copyright © 2022 Elsevier Ltd. All rights reserved.

Dados da publicação

ISSN/ISSNe:
1873-3735, 0165-6147

Trends in Pharmacological Sciences  Elsevier Ltd.

Tipo:
Review
Páginas:
806-819
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 9

Citações Recebidas na Scopus: 8

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Keywords

  • SMOOTH-MUSCLE-CELLS; NA+,K+-ATPASE ACTIVITY; PROTEIN-KINASE; INHIBITION; TRANSCRIPTION; NETWORK; SIK2

Proyectos asociados

Modelling Propofol pharmacokinetics and pharmacodynamics during an intravenous anaesthesia guided by the bispectral index (Bis)

Investigador Principal: Patrício Manuel Vieira Araújo Soares da Silva

Estudo Clínico Académico . 2021

Inervação simpática e mecanismos adrenérgicos locais na regulação funcional da córnea

Investigador Principal: Patrício Manuel Vieira Araújo Soares da Silva

Estudo Clínico Académico . 2019

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