A systematic review on experimental studies about patient adherence to treatment

Data de publicação: 01/01/2024

Autores da FMUP

• Rute Sofia Monteiro Sampaio

  Autor

• João De Almeida Lopes Da Fonseca

  Autor

Participantes de fora da FMUP

• Folkvord, F
• W?rth, ARU
• van Houten, K
• Liefveld, AR
• Carlson, JI
• Bol, N
• Krahmer, E
• Beets, G
• Ollerton, RD
• Turk, E
• Hrubos Strom, H
• Nahoui, H
• Einvik, G
• Schirmer, H
• Moen, A
• Barrio Cortes, J
• Merino Barbancho, B
• Arroyo, P
• Fico, G
• Mid?o, L.
• Geipel, K
• Scheckenbach, K
• de Ruiter, LE
• Lupi??ez Villanueva, F

Unidades de investigação

• Biomedicina

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Medicina da Comunidade, Informação e Decisão em Saúde

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

A better understanding of patients adherence to treatment is a prerequisite to maximize the benefit of healthcare provision for patients, reduce treatment costs, and is a key factor in a variety of subsequent health outcomes. We aim to understand the state of the art of scientific evidence about which factors influence patients adherence to treatment. A systematic literature review was conducted using PRISMA guidelines in five separate electronic databases of scientific publications: PubMed, PsycINFO (ProQuest), Cochrane library (Ovid), Google Scholar, and Web of Science. The search focused on literature reporting the significance of factors in adherence to treatment between 2011 and 2021, including only experimental studies (e.g., randomized controlled trials [RCT], clinical trials, etc.). We included 47 experimental studies. The results of the systematic review (SR) are grouped according to predetermined categories of the World Health Organization (WHO): socioeconomic, treatment, condition, personal, and healthcare-related factors. This review gives an actual overview of evidence-based studies on adherence and analyzed the significance of factors defined by the WHO classification. By showing the strength of certain factors in several independent studies and concomitantly uncovering gaps in research, these insights could serve as a basis for the design of future adherence studies and models. image

© 2024 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd.

Keywords

• dimensions; experimental studies; factors; medication; patient adherence; systematic review