Portal de investigação
Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Louis, Gilles
- Czarlewski, Wienczyslawa
- Anto, Josep M.
- Brussino, Luisa
- Canonica, G. Walter
- Loureiro, Claudia Chaves
- Cruz, Alvaro A.
- Gemicioglu, Bilun
- Haahtela, Tari
- Kupczyk, Maciej
- Kvedariene, Violeta
- Larenas-Linnemann, Desiree E.
- Pham-Thi, Nhan
- Puggioni, Francesca
- Regateiro, Frederico S.
- Romantowski, Jan
- Sastre, Joaquin
- Scichilone, Nicola
- Taborda-Barata, Luis
- Ventura, Maria Teresa
- Agache, Ioana
- Bedbrook, Anna
- Benfante, Alida
- Bergmann, Karl C.
- Bosnic-Anticevich, Sinthia
- Bonini, Matteo
- Boulet, Louis-Philippe
- Brusselle, Guy
- Buhl, Roland
- Cecchi, Lorenzo
- Charpin, Denis
- Costa, Elisio M.
- Del Giacco, Stefano
- Jutel, Marek
- Klimek, Ludger
- Kuna, Piotr
- Laune, Daniel
- Makela, Mika
- Morais-Almeida, Mario
- Nadif, Rachel
- Niedoszytko, Marek
- Papadopoulos, Nikolaos G.
- Papi, Alberto
- Pfaar, Oliver
- Rivero-Yeverino, Daniela
- Roche, Nicolas
- Samolinski, Boleslaw
- Shamji, Mohamed H.
- Sheikh, Aziz
- Ulrik, Charlotte Suppli
- Usmani, Omar S.
- Valiulis, Arunas
- Yorgancioglu, Arzu
- Zuberbier, Torsten
- Petre, Benoit
- Louis, Renaud
- Bousquet, Jean
- MASK Air Think Tank
Unidades de investigação
Abstract
RationaleIt is unclear how each individual asthma symptom is associated with asthma diagnosis or control.ObjectivesTo assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control.MethodsIn this cross-sectional study, we assessed real-world data using the MASK-air (R) app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma.Measurement and Main ResultsWe included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma.ConclusionsWheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
© 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
Dados da publicação
- ISSN/ISSNe:
- 2045-7022, 2045-7022
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.1002/clt2.12358
- Link para outro recurso:
- www.scopus.com
Clinical and Translational Allergy John Wiley & Sons Inc.
Documentos
- Não há documentos
Filiações
Keywords
- asthma; diagnosis; dyspnea; mHealth; wheezing
Campos de estudo
Proyectos asociados
Prevalence and Characterisation of Asthma Patients According to Disease Severity in Portugal (EPI-ASTHMA) - NCT05169619
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Observacional (EPI-ASTHMA) . AstraZeneca . 2021
Effect of a Mobile App on Improving Asthma Control in Adolescents and Adults With Persistent Asthma: A Pilot Randomized Multicentre, Superiority Clinical Trial (mINSPIRERS) - NCT05129527
Investigador Principal: João de Almeida Lopes da Fonseca
Ensaio Clínico Académico (mINSPIRERS) . 2021
Utilização em estudos observacionais do Registo de Asma Grave Portugal.
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Observacional Académico (RAG) . 2020
Clinical Research Collaboration Severe Heterogenous Asthma Research collaboration, Patient-centered (CRC SHARP).
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Observacional (SHARP) . European Respiratory Society . 2021
Multidimensional phenotyping of severe asthma patients and its impact on disease control and therapeutic response - analysis from the Portuguese Severe Asthma Registry.
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Observacional (RAG-SPP-GSK) . SPPneumologia . 2022
BREATHE - An oBservational, pRimary data study to characterize severe AsThma pHenotypes and assEss disease burden across the EUCAN region.
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Observacional (RAG-AZ-BREATHE) . AstraZeneca . 2022
Seroprevalence of SARS-CoV-2 and assessment of epidemiologic determinants in Portuguese municipal workers
Investigador Principal: Bernardo Manuel De Sousa Pinto
Estudo Clínico Académico (SARS-CoV-2) . 2021
Efficiency in Spine Care ? Assessing outcomes and costs to inform healthcare improvement
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Académico . 2022
Use of secondary data, health technology assessment methods and economic modelling applied to penicillin allergy
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Académico . 2020
Using different data sources for the identification of asthma patients and those at high risk of adverse outcomes
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Académico . 2020
Phenotypes of Chronic Diseases of the Airways: Towards Multidimensional Data -Driven Profiling
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Académico . 2020
Citar a publicação
Sousa B,Louis G,Vieira RJ,Czarlewski W,Anto JM,Amaral R,Sa A,Brussino L,Canonica GW,Loureiro CC,Cruz AA,Gemicioglu B,Haahtela T,Kupczyk M,Kvedariene V,Larenas DE,Pham N,Puggioni F,Regateiro FS,Romantowski J,Sastre J,Scichilone N,Taborda L,Ventura MT,Agache I,Bedbrook A,Benfante A,Bergmann KC,Bosnic S,Bonini M,Boulet L,Brusselle G,Buhl R,Cecchi L,Charpin D,Costa EM,Del Giacco S,Jutel M,Klimek L,Kuna P,Laune D,Makela M,Morais M,Nadif R,Niedoszytko M,Papadopoulos NG,Papi A,Pfaar O,Rivero D,Roche N,Samolinski B,Shamji MH,Sheikh A,Ulrik CS,Usmani OS,Valiulis A,Yorgancioglu A,Zuberbier T,Fonseca JA,Petre B,Louis R,Bousquet J,MASK Air Think T. Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study. Clin. Transl. Allergy. 2024. 14. (6):e12358. IF:4,400. (2).
