Portal de investigação
Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Wechsler, Michael E.
- Scelo, Ghislaine
- Larenas-Linnemann, Esiree E. S.
- Torres-Duque, Carlos A.
- Maspero, Jorge
- Tran, Trung N.
- Murray, Ruth B.
- Martin, Neil
- Menzies-Gow, Andrew N.
- Hew, Mark
- Peters, Matthew J.
- Gibson, Peter G.
- Christoff, George C.
- Popov, Todor A.
- Cote, Andreanne
- Bergeron, Celine
- Dorscheid, Delbert
- FitzGerald, J. Mark
- Chapman, Kenneth R.
- Boulet, Louis Philippe
- Bhutani, Mohit
- Sadatsafavi, Mohsen
- Jimenez-Maldonado, Libardo
- Duran-Silva, Mauricio
- Rodriguez, Bellanid
- Celis-Preciado, Carlos Andres
- Cano-Rosales, Diana Jimena
- Solarte, Ivan
- Fernandez-Sanchez, Maria Jose
- Parada-Tovar, Patricia
- von Bulow, Anna
- Bjerrum, Anne Sofie
- Ulrik, Charlotte S.
- Assing, Karin Dahl
- Rasmussen, Linda Makowska
- Hansen, Susanne
- Altraja, Alan
- Bourdin, Arnaud
- Taille, Camille
- Charriot, Jeremy
- Roche, Nicolas
- Papaioannou, Andriana I.
- Kostikas, Konstantinos
- Papadopoulos, Nikolaos G.
- Salvi, Sundeep
- Long, Deirdre
- Mitchell, Patrick D.
- Costello, Richard
- Sirena, Concetta
- Cardini, Cristina
- Heffler, Enrico
- Puggioni, Francesca
- Canonica, Giorgio Walter
- Guida, Giuseppe
- Iwanaga, Takashi
- Al-Ahmad, Mona
- Garcia, Ulises
- Kuna, Piotr
- Al-Lehebi, Riyad
- Koh, Mariko S.
- Rhee, Chin Kook
- Cosio, Borja G.
- de Llano, Luis Perez
- Perng, Diahn-Warng (Steve)
- Huang, Erick Wan-Chun
- Wang, Hao-Chien
- Tsai, Ming-Ju
- Mahboub, Bassam
- Salameh, Laila Ibraheem Jaber
- Jackson, David J.
- Busby, John
- Heaney, Liam G.
- Pfeffer, Paul E.
- Goddard, Amanda Grippen
- Wang, Eileen
- Hoyte, Flavia C. L.
- Chapman, Nicholas M.
- Katial, Rohit
- Carter, Victoria
- Bulathsinhala, Lakmini
- Eleangovan, Neva
- Ariti, Con
- Lyu, Juntao
- Porsbjerg, Celeste
- Price, David B.
Unidades de investigação
Abstract
Rationale: Previous studies investigating the impact of comorbidities on the effectiveness of biologic agents have been relatively small and of short duration and have not compared classes of biologic agents. Objectives: To determine the association between type 2-related comorbidities and biologic agent effectiveness in adults with severe asthma (SA). Methods: This cohort study used International Severe Asthma Registry data from 21 countries (2017-2022) to quantify changes in four outcomes before and after biologic therapy-annual asthma exacerbation rate, FEV1% predicted, asthma control, and long-term oral corticosteroid daily dose-in patients with or without allergic rhinitis, chronic rhinosinusitis (CRS) with or without nasal polyps (NPs), NPs, or eczema/atopic dermatitis. Measurements and Main Results: Of 1,765 patients, 1,257, 421, and 87 initiated anti-IL-5/5 receptor, anti-IgE, and anti-IL-4/13 therapies, respectively. In general, pre- versus post-biologic therapy improvements were noted in all four asthma outcomes assessed, irrespective of comorbidity status. However, patients with comorbid CRS with or without NPs experienced 23% fewer exacerbations per year (95% CI, 10-35%; P < 0.001) and had 59% higher odds of better post-biologic therapy asthma control (95% CI, 26-102%; P < 0.001) than those without CRS with or without NPs. Similar estimates were noted for those with comorbid NPs: 22% fewer exacerbations and 56% higher odds of better post-biologic therapy control. Patients with SA and CRS with or without NPs had an additional FEV1% predicted improvement of 3.2% (95% CI, 1.0-5.3; P = 0.004), a trend that was also noted in those with comorbid NPs. The presence of allergic rhinitis or atopic dermatitis was not associated with post-biologic therapy effect for any outcome assessed. Conclusions: These findings highlight the importance of systematic comorbidity evaluation. The presence of CRS with or without NPs or NPs alone may be considered a predictor of the effectiveness of biologic agents in patients with SA.
Dados da publicação
- ISSN/ISSNe:
- 1073-449X, 1535-4970
- Tipo:
- Article
- Páginas:
- 262-272
American Journal of Respiratory and Critical Care Medicine American Thoracic Society
Citações Recebidas na Web of Science: 9
Documentos
- Não há documentos
Filiações
Keywords
- allergic rhinitis; chronic rhinosinusitis; nasal polyposis
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Investigador Principal: João de Almeida Lopes da Fonseca
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Investigador Principal: João de Almeida Lopes da Fonseca
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Estudo Clínico Académico . 2022
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Estudo Clínico Académico . 2020
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Citar a publicação
Wechsler ME,Scelo G,Larenas EES,Torres CA,Maspero J,Tran TN,Murray RB,Martin N,Menzies AN,Hew M,Peters MJ,Gibson PG,Christoff GC,Popov TA,Cote A,Bergeron C,Dorscheid D,FitzGerald JM,Chapman KR,Boulet LP,Bhutani M,Sadatsafavi M,Jimenez L,Duran M,Rodriguez B,Celis CA,Cano DJ,Solarte I,Fernandez MJ,Parada P,von A,Bjerrum AS,Ulrik CS,Assing KD,Rasmussen LM,Hansen S,Altraja A,Bourdin A,Taille C,Charriot J,Roche N,Papaioannou AI,Kostikas K,Papadopoulos NG,Salvi S,Long D,Mitchell PD,Costello R,Sirena C,Cardini C,Heffler E,Puggioni F,Canonica GW,Guida G,Iwanaga T,Al M,Garcia U,Kuna P,Fonseca JA,Al R,Koh MS,Rhee CK,Cosio BG,de Llano LP,Perng D(,Huang EW,Wang H,Tsai M,Mahboub B,Salameh LIJ,Jackson DJ,Busby J,Heaney LG,Pfeffer PE,Goddard AG,Wang E,Hoyte FCL,Chapman NM,Katial R,Carter V,Bulathsinhala L,Eleangovan N,Ariti C,Lyu J,Porsbjerg C,Price DB. Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma. Am. J. Respir. Crit. Care Med. 2024. 209. (3):p. 262-272. IF:24,700. (1).
