Portal de investigação
Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Wechsler, Michael E.
- Scelo, Ghislaine
- Larenas-Linnemann, Esiree E. S.
- Torres-Duque, Carlos A.
- Maspero, Jorge
- Tran, Trung N.
- Murray, Ruth B.
- Martin, Neil
- Menzies-Gow, Andrew N.
- Hew, Mark
- Peters, Matthew J.
- Gibson, Peter G.
- Christoff, George C.
- Popov, Todor A.
- Cote, Andreanne
- Bergeron, Celine
- Dorscheid, Delbert
- FitzGerald, J. Mark
- Chapman, Kenneth R.
- Boulet, Louis Philippe
- Bhutani, Mohit
- Sadatsafavi, Mohsen
- Jimenez-Maldonado, Libardo
- Duran-Silva, Mauricio
- Rodriguez, Bellanid
- Celis-Preciado, Carlos Andres
- Cano-Rosales, Diana Jimena
- Solarte, Ivan
- Fernandez-Sanchez, Maria Jose
- Parada-Tovar, Patricia
- von Bulow, Anna
- Bjerrum, Anne Sofie
- Ulrik, Charlotte S.
- Assing, Karin Dahl
- Rasmussen, Linda Makowska
- Hansen, Susanne
- Altraja, Alan
- Bourdin, Arnaud
- Taille, Camille
- Charriot, Jeremy
- Roche, Nicolas
- Papaioannou, Andriana I.
- Kostikas, Konstantinos
- Papadopoulos, Nikolaos G.
- Salvi, Sundeep
- Long, Deirdre
- Mitchell, Patrick D.
- Costello, Richard
- Sirena, Concetta
- Cardini, Cristina
- Heffler, Enrico
- Puggioni, Francesca
- Canonica, Giorgio Walter
- Guida, Giuseppe
- Iwanaga, Takashi
- Al-Ahmad, Mona
- Garcia, Ulises
- Kuna, Piotr
- Al-Lehebi, Riyad
- Koh, Mariko S.
- Rhee, Chin Kook
- Cosio, Borja G.
- de Llano, Luis Perez
- Perng, Diahn-Warng (Steve)
- Huang, Erick Wan-Chun
- Wang, Hao-Chien
- Tsai, Ming-Ju
- Mahboub, Bassam
- Salameh, Laila Ibraheem Jaber
- Jackson, David J.
- Busby, John
- Heaney, Liam G.
- Pfeffer, Paul E.
- Goddard, Amanda Grippen
- Wang, Eileen
- Hoyte, Flavia C. L.
- Chapman, Nicholas M.
- Katial, Rohit
- Carter, Victoria
- Bulathsinhala, Lakmini
- Eleangovan, Neva
- Ariti, Con
- Lyu, Juntao
- Porsbjerg, Celeste
- Price, David B.
Unidades de investigação
Abstract
Rationale: Previous studies investigating the impact of comorbidities on the effectiveness of biologic agents have been relatively small and of short duration and have not compared classes of biologic agents. Objectives: To determine the association between type 2-related comorbidities and biologic agent effectiveness in adults with severe asthma (SA). Methods: This cohort study used International Severe Asthma Registry data from 21 countries (2017-2022) to quantify changes in four outcomes before and after biologic therapy-annual asthma exacerbation rate, FEV1% predicted, asthma control, and long-term oral corticosteroid daily dose-in patients with or without allergic rhinitis, chronic rhinosinusitis (CRS) with or without nasal polyps (NPs), NPs, or eczema/atopic dermatitis. Measurements and Main Results: Of 1,765 patients, 1,257, 421, and 87 initiated anti-IL-5/5 receptor, anti-IgE, and anti-IL-4/13 therapies, respectively. In general, pre- versus post-biologic therapy improvements were noted in all four asthma outcomes assessed, irrespective of comorbidity status. However, patients with comorbid CRS with or without NPs experienced 23% fewer exacerbations per year (95% CI, 10-35%; P < 0.001) and had 59% higher odds of better post-biologic therapy asthma control (95% CI, 26-102%; P < 0.001) than those without CRS with or without NPs. Similar estimates were noted for those with comorbid NPs: 22% fewer exacerbations and 56% higher odds of better post-biologic therapy control. Patients with SA and CRS with or without NPs had an additional FEV1% predicted improvement of 3.2% (95% CI, 1.0-5.3; P = 0.004), a trend that was also noted in those with comorbid NPs. The presence of allergic rhinitis or atopic dermatitis was not associated with post-biologic therapy effect for any outcome assessed. Conclusions: These findings highlight the importance of systematic comorbidity evaluation. The presence of CRS with or without NPs or NPs alone may be considered a predictor of the effectiveness of biologic agents in patients with SA.
Dados da publicação
- ISSN/ISSNe:
- 1073-449X, 1535-4970
- Tipo:
- Article
- Páginas:
- 262-272
- PubMed:
- 38016003
American Journal of Respiratory and Critical Care Medicine American Thoracic Society
Citações Recebidas na Web of Science: 9
Documentos
- Não há documentos
Filiações
Keywords
- allergic rhinitis; chronic rhinosinusitis; nasal polyposis
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