Protocol for the systematic reviews on the desirable and undesirable effects of pharmacological treatments of allergic rhinitis informing the ARIA 2024 guidelines.

Data de publicação: 22/07/2024 Data Ahead of Print: 22/07/2024

Autores da FMUP

João De Almeida Lopes Da Fonseca

Autor

Participantes de fora da FMUP

Vieira RJ
Torres MI
Bognanni A
Gil-Mata S
Ferreira-da-Silva R
Lourenço-Silva N
Cardoso-Fernandes A
Ferreira A
Ferreira-Cardoso H
Teles J
Campos-Lopes M
Yepes-Nuñez JJ
Klimek L
Zuberbier T
Schünemann H
Bousquet J
Sousa-Pinto B

Unidades de investigação

Laboratório Associado RISE- Rede de Investigação em Saúde

Investigador

Fernando Carlos De Landér Schmitt
Medicina da Comunidade, Informação e Decisão em Saúde
RISE-Health

Investigador

Fernando Carlos De Landér Schmitt

Abstract

There is insufficient evidence regarding the comparative efficacy and safety of pharmacological treatments of allergic rhinitis (AR). In the context of informing the 2024 revision of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines, we plan to perform three systematic reviews of randomized controlled trials (RCTs) comparing the desirable and undesirable effects (i) between intranasal and oral medications for AR; (ii) between combinations of intranasal and oral medications versus nasal or oral medications alone; and (iii) among different intranasal specific medications. We will search four electronic bibliographic databases and three clinical trials databases for RCTs examining patients = 12 years old with seasonal or perennial AR. Assessed outcomes will include the Total Nasal Symptom Score, the Total Ocular Symptom Score, and the Rhinoconjunctivitis Quality-of-Life Questionnaire. We will assess the methodological quality of included primary studies by using the Cochrane risk-of-bias tool. If appropriate, we will perform a pairwise random-effects meta-analysis for each pair of assessed medication classes and outcomes, as well as a network meta-analysis to assess the comparative efficacy of intranasal medications among each other. Heterogeneity will be explored by sensitivity and subgroup analyses. This set of systematic reviews will allow for a comprehensive assessment of the effectiveness and safety of pharmacological interventions for AR and inform recommendations in the context of the ARIA guidelines.

Dados da publicação

ISSN/ISSNe:: 0344-5062, 2512-8957
Tipo:: Article
Páginas:: 270-277
DOI:: 10.5414/ALX02515E

Documentos

Não há documentos

Métricas

Filiações

Vieira RJ:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Torres MI:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Bognanni A:: Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, ON, Canada
Gil-Mata S:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Ferreira-da-Silva R:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Lourenço-Silva N:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Cardoso-Fernandes A:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Ferreira A:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal

Department of Ophthalmology, Centro Hospitalar Universitário do Porto, Porto, Portugal
Ferreira-Cardoso H:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Teles J:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Campos-Lopes M:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Fonseca JA:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Yepes-Nuñez JJ:: School of Medicine, Universidad de los Andes, Bogotá, Colombia
Bousquet J:: ARIA, Montpellier, France
Sousa-Pinto B:: CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal

Keywords

allergic rhinitis; allergy; antihistamines; corticosteroids; quality of life