Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries-The @IT.2020 multicenter study.

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • José Luís Dias Delgado

    Autor

  • João De Almeida Lopes Da Fonseca

    Autor

  • Ana Margarida Barbosa Ribeiro Pereira

    Autor

Participantes de fora da FMUP

  • Dramburg S
  • Grittner U
  • Potapova E
  • Travaglini A
  • Tripodi S
  • Arasi S
  • Pelosi S
  • Acar Sahin A
  • Aggelidis X
  • Barbalace A
  • Bourgoin A
  • Bregu B
  • Brighetti MA
  • Caeiro E
  • Caglayan Sozmen S
  • Caminiti L
  • Charpin D
  • Couto M
  • Di Rienzo Businco A
  • Dimier C
  • Dimou MV
  • Goksel O
  • Hernandez D
  • Hernandez Toro CJ
  • Hoffmann TM
  • Jang DT
  • Kalpaklioglu F
  • Lame B
  • Llusar R
  • Makris M
  • Mazon A
  • Mesonjesi E
  • Nieto A
  • Öztürk AB
  • Pahus L
  • Pajno G
  • Panasiti I
  • Papadopoulos NG
  • Pellegrini E
  • Pereira M
  • Pinar NM
  • Priftanji A
  • Psarros F
  • Sackesen C
  • Sfika I
  • Suarez J
  • Thibaudon M
  • Uguz U
  • Verdier V
  • Villella V
  • Xepapadaki P
  • Yazici D
  • Matricardi PM

Unidades de investigação

Abstract

BACKGROUND: Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central and Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern European countries with a standardized approach. OBJECTIVE: To describe sensitization profiles and clinical phenotypes of pollen allergic patients in nine Southern European cities with a uniform methodological approach. METHODS: Within the @IT.2020 multicenter observational study, pediatric and adult patients suffering from SAR were recruited in nine urban study centers located in seven countries. Clinical questionnaires, skin prick tests (SPT) and specific IgE (sIgE) tests with a customized multiplex assay (Euroimmun Labordiagnostika, Lübeck, Germany) were performed. RESULTS: Three hundred forty-eight children (mean age 13.1 years, SD: 2.4 years) and 467 adults (mean age 35.7 years SD: 10.0 years) with a predominantly moderate to severe, persistent phenotype of SAR were recruited. Grass pollen major allergenic molecules (Phl p 1 and/or Phl p 5) ranged among the top three sensitizers in all study centers. Sensitization profiles were very heterogeneous, considering that patients in Rome were highly poly-sensitized (sIgE to 3.8 major allergenic molecules per patient), while mono-sensitization was prominent and heterogeneous in other cities, such as Marseille (sIgE to Cup a 1: n = 55/80, 68.8%) and Messina (sIgE to Par j 2: n = 47/82, 57.3%). Co-sensitization to perennial allergens, as well as allergic comorbidities also broadly varied between study centers. CONCLUSIONS: In Southern European countries, pollen allergy is heterogeneous in terms of sensitization profiles and clinical manifestations. Despite the complexity, a unique molecular, multiplex, and customized in-vitro IgE test detected relevant sensitization in all study centers. Nevertheless, this geographical diversity in pollen allergic patients imposes localized clinical guidelines and study protocols for clinical trials of SAR in this climatically complex region.

© 2024 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Dados da publicação

ISSN/ISSNe:
0105-4538, 1398-9995

ALLERGY  Wiley-Blackwell Publishing Ltd

Tipo:
Article
Páginas:
908-923
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 4

Citações Recebidas na Scopus: 3

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Keywords

  • IgE; allergic rhinitis; component-resolved diagnostics; phenotypes; pollen allergy; sensitization

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