Portal de investigação
Health-related quality of life and disability in adults with juvenile idiopathic arthritis: comparison with adult-onset rheumatic diseases.
Autores da FMUP
Participantes de fora da FMUP
- Oliveira Ramos F
- Magalhaes Martins F
- Melo AT
- Aguiar F
- Brites L
- Azevedo S
- Duarte AC
- Furtado C
- Mourão AF
- Sequeira G
- Cunha I
- Figueira R
- Melo Gomes JA
- Santos MJ
- Fonseca JE
Unidades de investigação
Abstract
OBJECTIVE: To compare physical disability, mental health, fatigue and health-related quality of life (HRQoL) across juvenile idiopathic arthritis (JIA) categories in adulthood and between JIA and adult-onset rheumatic diseases. METHODS: Cross-sectional analysis nested in a cohort of adult patients with JIA registered in the Rheumatic Diseases Portuguese Register (Reuma.pt). Physical disability (Health Assessment Questionnaire-Disability Index), mental health symptoms (Hospital Anxiety and Depression Scale), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT-F)) and HRQoL (EuroQol-5D (EQ5D) and Short Form (SF-36)) were compared across JIA categories. Patients with polyarticular JIA and enthesis-related arthritis (ERA) JIA were compared respectively to patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA), matched for gender and age, adjusted for disease duration and activity. RESULTS: 585 adult patients with JIA were included. Comparison across JIA categories showed that persistent oligoarthritis and patients with ERA reported a higher score in EQ5D and SF-36 physical component when compared with other JIA categories.Polyarticular JIA reported less disability and fatigue than patients with RA (median Health Assessment Questionnaire of 0.25 vs 0.63; p<0.001 and median FACIT-F score 42 vs 40 ; p=0.041). Polyarticular JIA had also better scores on EQ5D and all domains of SF-36, than patients with RA. Patients with ERA reported less depression and anxiety symptoms (0% vs 14.8%; p=0.003% and 9% vs 21.3%; p=0.002) and less fatigue symptoms (45 vs 41; p=0.01) than patients with SpA. CONCLUSION: Persistent oligoarticular JIA and ERA are the JIA categories in adulthood with better HRQoL. Overall, adult polyarticular and patients with ERA JIA have lower functional impairment and better quality-of-life than patients with RA and SpA.
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Dados da publicação
- ISSN/ISSNe:
- 2056-5933, 2056-5933
- Tipo:
- Article
- Páginas:
- -
RMD Open BMJ Publishing Group
Documentos
- Não há documentos
Filiações
Keywords
- ankylosing; arthritis; juvenile; patient reported outcome measures; rheumatoid; spondylitis
Campos de estudo
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Citar a publicação
Oliveira F,Rodrigues A,Magalhaes F,Melo AT,Aguiar F,Brites L,Azevedo S,Duarte AC,Furtado C,Mourão AF,Sequeira G,Cunha I,Figueira R,Melo JA,Santos MJ,Fonseca JE. Health-related quality of life and disability in adults with juvenile idiopathic arthritis: comparison with adult-onset rheumatic diseases. RMD Open. 2021. 7. (3):IF:5,806. (1).
