Portal de investigação
Does autosomal dominant polycystic kidney disease increase the risk of aortic aneurysm or dissection: a point of view based on a systematic review and meta-analysis.
Autores da FMUP
Participantes de fora da FMUP
- Gouveia E Melo R
- Almeida AG
- de Almeida E
- Pinto FJ
- Pedro LM
- Caldeira D
Unidades de investigação
Abstract
Autosomal Dominant Polycystic Kidney Disease (ADPKD) has several renal and extra-renal manifestations. Studies have reported a higher incidence of aortic aneurysms (AAs)/aortic dissections (ADs) in these patients, and we believe ADPKD should be considered as a risk factor for AA/AD. In order to support our opinion we conducted a systematic review and meta-analysis analyzing the risk of AA/AD in ADPKD patients.We searched MEDLINE, CENTRAL, PsycInfo, Web of Science Core Collection and OpenGrey for observational studies reporting frequency estimates of AA/AD in ADPKD patients compared with controls. We analyzed the odds ratio (OR) of the existence of an AA/AD in patients with ADPKD compared to controls. We also analyzed the odds of having an AA in patients with ADPKD compared to controls, the odds of having an AD in patients with ADPKD compared to controls, differences among subtypes of AA or AD, differences according to age, gender and different study designs.Seven observational studies were included. ADPKD was associated with a higher risk of AA or AD as compared with a population without the disease (OR 4.33; 95% CI 2.69; 6.97, p < 0.001); higher risk of AA (OR 4.18; 95% CI 2.36; 7.40, p < 0.001) and higher risk of AD (OR 9.08; 95% CI 3.11; 26.55, p < 0.001).Our point of view, suggesting the inclusion of aortic aneurysms and aortic dissection in the potential complications of ADPKD, was supported by our systematic review and meta-analysis showing that ADPKD was associated with a significant risk of having/developing an AA/AD. However, the risk of bias of included studies was considered high and these results should be interpreted cautiously. This association should be considered in clinical practice, although further studies are needed to consolidate these findings.
© 2022. The Author(s) under exclusive licence to Italian Society of Nephrology.
Dados da publicação
- ISSN/ISSNe:
- 1724-6059, 1121-8428
- Tipo:
- Article
- Páginas:
- 1585-1593
Journal of Nephrology Wichtig Publishing Srl
Documentos
- Não há documentos
Filiações
Keywords
- ADPKD; Aortic aneurysms; Aortic dissections; Meta-analysis; Systematic review
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Citar a publicação
Nunes R,Gouveia E Melo R,Almeida AG,de Almeida E,Pinto FJ,Pedro LM,Caldeira D. Does autosomal dominant polycystic kidney disease increase the risk of aortic aneurysm or dissection: a point of view based on a systematic review and meta-analysis. J. Nephrol. 2022. 35. (6):p. 1585-1593. IF:3,400. (2).
