Extended Endocrine Therapy for Early-Stage Breast Cancer: How Do We Decide?

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Rui Manuel Lopes Nunes

    Autor

Participantes de fora da FMUP

  • Walsh EM
  • Wilkinson MJ
  • Santa-Maria CA

Unidades de investigação

Abstract

PURPOSE OF REVIEW: While the majority of hormone receptor-positive breast cancers are diagnosed at an early stage, a significant proportion of patients will develop disease recurrence, especially late disease recurrence, despite current therapeutic approaches. In this review, we examine the data pertaining to the choice of endocrine and extended endocrine therapy, outline how to identify patients that may benefit from extended therapy, and discuss prognostic tools to assist with patient selection. RECENT FINDINGS: The risk of breast cancer recurrence persists after 5 years, is cumulative, and is indefinite. In attempts to mitigate these risks, studies have evaluated the use of extended endocrine therapy. Overall survival benefit has been demonstrated with extended tamoxifen, whereas extended aromatase inhibitors have shown modest disease-free survival benefit. Therapeutic approaches for individual patients will depend on the perceived risk of recurrence, likely benefit of extended therapy, tolerability of current endocrine therapy, and patient preference.

Dados da publicação

ISSN/ISSNe:
1534-6269, 1523-3790

Current Oncology Reports  Current Science, Inc.

Tipo:
Article
Páginas:
123-123

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Keywords

  • Breast cancer; Endocrine therapy; Extended endocrine therapy; Hormone receptor

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