Portal de investigação
Evaluation of IL-2, IL-4, IL-6, IL-10, TNF-a, and IFN-? cytokines in HIV/HHV-8 coinfection
Autores da FMUP
Participantes de fora da FMUP
- Silva, Dayvson Mauricio da
- Goncales, Juliana Prado
- Silva Junior, Jose Valter Joaquim
- Lopes, Thaisa Regina Rocha
- Bezerra, Luan Araujo
- Barros de Lorena, Virginia Maria
Unidades de investigação
Abstract
Imbalance in the immune response is one of the main pathogenic mechanisms of diseases related withhuman immunodeficiency virus(HIV)/human gammaherpesvirus 8(HHV-8) coinfection, such as Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and the Kaposi's sarcoma-associated herpesvirus inflammatory cytokine syndrome (KICS). However, significant changes in pro- and anti-inflammatory cytokine levels may be observed in HIV/HHV-8 individuals who are negative for KS, PEL, MCD, and/or KICS. In this study, serum levels of interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor nucrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) were assessed in 69 HIV and 48 HIV/HHV-8 individuals, all negatives for HHV-8-related diseases. The cytokines were measured by flow cytometry and analyzed by the Mann-Whitney test. Thep < .05 and 95% confidence interval were considered in all analyzes. IL-4 (p = .0155), IL-6 (p = .0036), and IL-10 (p = .0036) levels were significantly higher in HIV/HHV-8 patients than in the HIV group. On the other hand, IL-2 (p = .2295), TNF-alpha (p = .1216) and IFN-gamma (p = .1178) did not differ between the groups analyzed. To our knowledge, to date, this is the first report on significant differences in the levels of IL-4 and IL-6 in HIV versus HIV/HHV-8 individuals. Finally, these early findings are important as a prognostic tool and contribute to clarifying the HHV-8-host interaction.
Dados da publicação
- ISSN/ISSNe:
- 1096-9071, 0146-6615
- Tipo:
- Article
- Páginas:
- 4033-4037
- DOI:
- 10.1002/jmv.26516
- PubMed:
- 32926412
Journal of Medical Virology Wiley-Liss Inc.
Citações Recebidas na Web of Science: 7
Citações Recebidas na Scopus: 10
Documentos
- Não há documentos
Filiações
Keywords
- cytokine; HHV-8; HIV; KSHV; pathogenesis
Projetos associados
Ongoing Clinical Trials with Monoclonal Antibodies in Schizophrenia
Investigador Principal: Maria Augusta Vieira Coelho
Estudo Clínico Académico . 2020
Citar a publicação
Silva DMD,Goncales JP,Silva JVJ,Lopes TRR,Bezerra LA,Barros de Lorena VM,Duarte MRC. Evaluation of IL-2, IL-4, IL-6, IL-10, TNF-a, and IFN-? cytokines in HIV/HHV-8 coinfection. J. Med. Virol. 2021. 93. (6):p. 4033-4037. IF:20,693. (1).
