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  3. Microarchitectural parameters and bone mineral density in patients with tumour-induced osteomalacia by HR-pQCT and DXA

Microarchitectural parameters and bone mineral density in patients with tumour-induced osteomalacia by HR-pQCT and DXA

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Maria Augusta Vieira Coelho

    Autor

Participantes de fora da FMUP

  • Mendes, Danielle Alves Brandao
  • Gehrke, Barbara
  • Kasuki, Leandro
  • Cardoso Lima, Luis Felipe
  • Paranhos-Neto, Francisco
  • Mendonca, Laura Maria Carvalho de
  • Farias, Maria Lucia Fleiuss
  • Madeira, Miguel

Unidades de investigação

Abstract

Objective Tumour-induced osteomalacia (TIO) is a rare paraneoplastic condition characterized by decreased tubular phosphate reabsorption. The purpose of this study was to evaluate bone mineral density (BMD) and microarchitecture in six TIO patients compared with eighteen healthy controls. Design Volumetric BMD and microarchitecture were evaluated by high-resolution peripheral quantitative computerized tomography (HR-pQCT), and areal BMD was evaluated by dual-energy X-ray absorptiometry (DXA). Differences between groups were significant for p-value All TIO subjects were healthy until development of diffuse bone pain and multiple skeletal fractures and deformities. At baseline, sPi and TmPi/GFR were low and patients were on vitamin D and phosphate replacement at the study. Measurements and Results Compared with controls, TIO patients had lower aBMD at lumbar spine and hip, and lower vBMD at trabecular, cortical and entire bone, at distal radius (R) and distal tibia (T): Dtrab (R = 118.3 x 177.1; T = 72.3 x 161.3 gHA/cm(3)); Dcomp (R = 782.3 x 866.5; T = 789.1 x 900.9 gHA/cm(3)); and Dtotal (R = 234.5 x 317; T = 167.1 x 295.8 gHA/cm(3)). Bone microarchitecture was very heterogeneous among patients and significantly different from controls: lower Ct.Th (R = 0.59 x 0.80; T = 0.90 x 1.31 mm), BV/TV (R = 0.09 x 0.14; T = 0.06 x 0.13) and Tb.N (R = 1.46 x 2.10; T = 0.93 x 1.96 mm(-1)); and also higher Tb.Sp (R = 0.70 x 0.41; T = 1.28 x 0.45 mm) and Tb.1/N.SD (R = 0.42 x 0.18; T = 0.87 x 0.20 mm). Conclusion In this original study of TIO patients, DXA and HR-pQCT evaluation identified lower areal and volumetric BMD and severely impaired microarchitecture at cortical and trabecular bones, which probably contribute to bone fragility and fractures.

Dados da publicação

ISSN/ISSNe:
1365-2265, 0300-0664

Clinical Endocrinology  Wiley-Blackwell Publishing Ltd

Tipo:
Article
Páginas:
587-594
PubMed:
34043830

Citações Recebidas na Web of Science: 11

Citações Recebidas na Scopus: 12

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Keywords

  • bone density; bone microarchitecture; high-resolution peripheral quantitative computerized tomography (HR-pQCT); hypophosphatasia; osteomalacia

Campos de Estudo

Projetos associados

Ongoing Clinical Trials with Monoclonal Antibodies in Schizophrenia

Investigador Principal: Maria Augusta Vieira Coelho

Estudo Clínico Académico . 2020

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