Chikungunya virus as a trigger for different renal disorders: an exploratory study

Data de publicação: 01/06/2022 Data Ahead of Print: 01/02/2022

Autores da FMUP

Maria Augusta Vieira Coelho

Autor

Participantes de fora da FMUP

do Nascimento Costa, Denise Maria
Machado, Carlos Eduardo
Neves, Precil Diego
Brito, Dyego Jose
Oi, Samira
Barros, Flavio Henrique
Figueiredo, Luiz Tadeu
Almeida Araujo, Stanley
Ladchumananandasivam, Francisco
dos Reis, Marlene Antonia
Luchi, Weverton
Lages, Joyce
Salgado Filho, Natalino
Onuchic, Luiz Fernando
Duarte, Angela Luzia
Marques, Claudia Diniz Lopes
Oliveira, Camila
Vajgel, Gisele
Cavalcante, Maria Alina
Valente, Lucila
Magalhaes, Vera
Silva, Gyl Eanes Barros

Unidades de investigação

Biomedicina

Abstract

Introduction Chikungunya virus was detected in cases of acute chikungunya fever in renal tissue. However, chikungunya virus-related kidney injury still lacks characterization, and it is unknown whether the kidneys are reservoirs for the virus. We sought to detect histopathological changes and viral antigens in renal tissue, and to evaluate kidney injury markers in different phases of chikungunya fever. Methods Two groups were evaluated in this exploratory study: patients with biopsy-proven kidney injury established after chikungunya fever, and patients with post-chikungunya fever chronic joint manifestations without known kidney injury, in whom we actively searched for kidney injury markers. Results In the first group, 15 patients had kidney injury 0.5-24 months after chikungunya fever. The most frequent histopathological diagnoses were glomerular lesions. No viral antigens were detected in renal tissue. High-risk genotypes were detected in patients with atypical hemolytic uremic syndrome and focal and segmental glomerulosclerosis. In the second group, 114 patients had post-chikungunya fever joint manifestations on average for 35.6 months. Mean creatinine and proteinuria were 0.9 mg/dl and 71.5 mg/day, respectively. One patient had isolated hematuria. There was no indication for renal biopsy in this group. Conclusions Several histopathological features were found after chikungunya fever, without virus detection in renal tissue. These findings suggest that chikungunya virus may trigger kidney lesions with varying degrees of severity at different stages of infection. However, the probability that this virus replicates in the renal tissue seems unlikely. [GRAPHICS] .

Dados da publicação

ISSN/ISSNe:: 1724-6059, 1121-8428
Tipo:: Article
Páginas:: 1437-1447
DOI:: 10.1007/s40620-022-01256-6
PubMed:: 35119686

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Keywords

Chikungunya virus; Chikungunya fever; Kidney injury; Glomerulopathy

Campos de Estudo

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