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  3. Aerobic exercise improves central blood pressure and blood pressure variability among patients with resistant hypertension: results of the EnRicH trial

Aerobic exercise improves central blood pressure and blood pressure variability among patients with resistant hypertension: results of the EnRicH trial

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Jorge Manuel Da Silva Junqueira Polónia

    Autor

Participantes de fora da FMUP

  • Lopes, Susana
  • Mesquita-Bastos, Jose
  • Garcia, Catarina
  • Leitao, Catia
  • Ribau, Veronica
  • Teixeira, Manuel
  • Bertoquini, Susana
  • Ribeiro, Ilda P.
  • de Melo, Joana Barbosa
  • Oliveira, Jose
  • Figueiredo, Daniela
  • Guimaraes, Guilherme V.
  • Pescatello, Linda S.
  • Alves, Alberto J.
  • Ribeiro, Fernando

Unidades de investigação

Abstract

Central blood pressure (BP) and BP variability are associated with cardiovascular disease risk. However, the influence of exercise on these hemodynamic parameters is unknown among patients with resistant hypertension. The EnRicH (The Exercise Training in the Treatment of Resistant Hypertension) was a prospective, single-blinded randomized clinical trial (NCT03090529). Sixty patients were randomized to a 12-week aerobic exercise program or usual care. The outcome measures include central BP, BP variability, heart rate variability, carotid-femoral pulse wave velocity, and circulating cardiovascular disease risk biomarkers including high-sensitivity C-reactive protein, angiotensin II, superoxide dismutase, interferon gamma, nitric oxide, and endothelial progenitor cells. Central systolic BP decreased by 12.22 mm Hg (95% CI, -1.88 to -22.57, P = 0.022) as did BP variability by 2.85 mm Hg (95% CI, -4.91 to -0.78, P = 0.008), in the exercise (n = 26) compared to the control group (n = 27). Interferon gamma -4.3 pg/mL (95%CI, -7.1 to -1.5, P = 0.003), angiotensin II -157.0 pg/mL (95% CI, -288.1 to -25.9, P = 0.020), and superoxide dismutase 0.4 pg/mL (95%CI, 0.1-0.6, P = 0.009) improved in the exercise compared to the control group. Carotid-femoral pulse wave velocity, heart rate variability, high-sensitivity C-reactive protein, nitric oxide, and endothelial progenitor cells were not different between groups (P > 0.05). In conclusion, a 12-week exercise training program improved central BP and BP variability, and cardiovascular disease risk biomarkers in patients with resistant hypertension. These markers are clinically relevant as they are associated with target organ damage and increased cardiovascular disease risk and mortality.

Dados da publicação

ISSN/ISSNe:
1348-4214, 0916-9636

Hypertension Research  Nature Publishing Group

Tipo:
Article
Páginas:
1547-1557
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 10

Citações Recebidas na Scopus: 9

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Keywords

  • Exercise training; Central arterial pressure; Autonomic function; Arterial stiffness; Inflammation

Campos de estudo

Proyectos asociados

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Investigador Principal: Jorge Manuel da Silva Junqueira Polónia

Estudo Clínico Académico . 2021

Hipertensão da bata branca: prognóstico cardiovascular quando definida pela normalidade da pressão arterial noturna.

Investigador Principal: Jorge Manuel da Silva Junqueira Polónia

Estudo Clínico Académico . 2022

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