Non-Invasive versus Invasive Assessment of Portal Hypertension in Chronic Liver Disease

Autores da FMUP

• Manuel Guilherme Gonçalves Macedo

  Autor

Participantes de fora da FMUP

• Gaspar, Rui

Unidades de investigação

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Medicina

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Background: Cirrhosis is one of the major causes of morbidity and mortality worldwide and the second leading cause of digestive disease mortality. Portal hypertension is the main driver of cirrhosis-related complications such as ascites and variceal bleeding. Portal hypertension is defined as a hepatic venous pressure gradient >5 mm Hg, although it is clinically significant and associated with clinical complications when >10 mm Hg. Summary: Therefore, detection of clinically significant portal hypertension (CSPH) in chronic advanced liver disease or compensated cirrhosis is of paramount importance to guide the management of these patients. Key Messages: This study aimed at revising the non-invasive and invasive tools for assessment of portal hypertension and risk stratification for CSPH in patients with chronic liver disease. (c) 2024 The Author(s).Published by S. Karger AG, Base

Keywords

• Chronic liver disease; Transjugular liver biopsy; Non-invasive assessment; Liver elastography; Spleen elastrography; Doen & ccedil;a hep & aacute;tica cr & oacute;nica; Bi & oacute;psia hep & aacute;tica transjugular; Avalia & ccedil;& atilde;o n & atilde;o-invasiva; Elastografia hep & aacute;tica; Elastografia espl & eacute;nica