Portal de investigação
Ocular manifestations of Monkeypox virus (MPXV) infection with viral persistence in ocular samples: A case series
Autores da FMUP
Participantes de fora da FMUP
- Finamor, Luciana P. S.
- Mendes-Correa, Maria Cassia
- Rinkevicius, Monica
- Sabino, Ester Cerdeira
- Villas-Boas, Lucy Santos
- Paula, Anderson Vicente de
- de Araujo-Heliodoro, Raissa Heloisa
- da Costa, Antonio Charlys
- Witkin, Steven S.
- Santos, Keila Lima Carneiro
- Palmeira, Camila
- Andrade, Gabriel
- Lucena, Maurilio
- Santoro, Dalton de Freitas
- Silva, Luci Meire Pereira da
- de Freitas, Dalton
Unidades de investigação
Abstract
Objective: We describe the clinical presentation and ocular viral dynamics in patients with Monkeypox virus-related ophthalmic disease (MPXROD). Methods: In this case series, we investigated five consecuti ve patients with confirmed mpox, diagnosed through a positive Monkeypox virus (MPXV) Polymerase Chain Reaction (PCR) test and presenting with ocular symptoms. They were referred from the Reference Center for Sexually Transmitted Infections in S & atilde;o Paulo (CRT) to the Uveitis Sector at the Federal University of S & atilde;o Paulo, between August and December 2022. We performed PCR testing on ocular samples and culture supernatants for MPXV in all patients. Viral sequencing was conducted in one of the cases. Results: Replicating MPXV was identified in at least one ocular sample of all patients, between day 31 and day 145 after the onset of skin lesions. All patients presented with keratitis, 3 with uveitis (60%) and two exhibited hypopyon (40%). The onset of ocular symptoms occurred at a mean of 21.2 days after the appearance of the first skin lesion and persisted, on average, for 61,.6 days, with a worsening trend observed until the initiation of tecovirimat treatment. Tecovirimat treatment was administered to all patients, with initiation occurring between 31 and 145 days after the onset of skin lesions. MPXV genome sequencing of an isolate from one patient classified it as belonging to lineage B1 in clade IIb. Conclusion: This study reveals a late onset and persistence of sight threatening ocular disease, along with potential viral infectivity even after systemic resolution in mpox cases. These findings highlight the risk of ongoing transmission from individuals with prolonged ocular manifestations, particularly through ocular discharge. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
Dados da publicação
- ISSN/ISSNe:
- 1201-9712, 1878-3511
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 38710273
International Journal of Infectious Diseases Elsevier
Citações Recebidas na Web of Science: 4
Citações Recebidas na Scopus: 6
Documentos
- Não há documentos
Filiações
Keywords
- MPOX; Monkeypox virus-related ophthalmic; disease; Viral isolation; Keratitis; uveitis; Monkeypox virus
Projetos associados
The contribution of endoscopic ultrasound and biomarkers in the management of pancreatic adenocarcinoma and its precursor lesions.
Investigador Principal: Manuel Guilherme Gonçalves Macedo
Estudo Clínico Académico . 2023
Noninvasive serum biomarkers of portal hypertension in liver cirrhosis
Investigador Principal: Manuel Guilherme Gonçalves Macedo
Estudo Clínico Académico . 2023
Otimização do rendimento da colangiopancreatografia retrógrada endoscópica na avaliação das estenoses pancreato-biliares indeterminadas
Investigador Principal: Manuel Guilherme Gonçalves Macedo
Estudo Clínico Académico . 2023
Endoscopic Treatment Of Upper Gastrointestinal Postsurgical Leaks
Investigador Principal: Manuel Guilherme Gonçalves Macedo
Estudo Clínico Académico . 2023
Citar a publicação
Finamor LPS,Mendes MC,Rinkevicius M,Macedo G,Sabino EC,Villas LS,Paula AVD,de Araujo RH,da AC,Witkin SS,Santos KLC,Palmeira C,Andrade G,Lucena M,Santoro DF,Silva LMPD,de Freitas D. Ocular manifestations of Monkeypox virus (MPXV) infection with viral persistence in ocular samples: A case series. Int. J. Infect. Dis. 2024. 146. 107071. IF:8,400. (1).
