Portal de investigação
Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Razavi-Shearer, Devin M.
- Buti, Maria
- Tacke, Frank
- Terrault, Norah A.
- Zeuzem, Stefan
- Abbas, Zaigham
- Aghemo, Alessio
- Akarca, Ulus S.
- Al Masri, Nasser M.
- Alalwan, Abduljaleel M.
- Blome, Marianne Alanko
- Aleman, Soo
- Alghamdi, Abdullah S.
- Alghamdi, Mohammed
- Alghamdi, Saad
- Al-Hamoudi, Waleed K.
- Ali, Ela
- Aljumah, Abdulrahman A.
- Altraif, Ibrahim H.
- Amarsanaa, Jazag
- Asselah, Tarik
- Baatarkhuu, Oidov
- Babameto, Adriana
- Ben-Ari, Ziv
- Berg, Thomas
- Biondi, Mia J.
- Braga, Wornei S. M.
- Brandao-Mello, Carlos E.
- Brown, Jr., Robert S.
- Brunetto, Maurizia R.
- Cabezas, Joaquin
- Cardoso, Mariana
- Chan, Henry Lik Yuen
- Cheinquer, Hugo
- Chen, Chien-Jen
- Chen, Pei-Jer
- Chien, Cheng-Hung
- Child, Hailey
- Chuang, Wan-Long
- Garza, Laura E. Cisneros
- Coco, Barbara
- Coffin, Carla S.
- Coppola, Nicola
- Cornberg, Markus
- Craxi, Antonio
- Crespo, Javier
- Cuko, Liri
- De Ledinghen, Victor
- Duberg, Ann-Sofi
- Etzion, Ohad
- Ferraz, Maria Lucia G.
- Ferreira, Paulo R. A.
- Forns, Xavier
- Foster, Graham R.
- Fung, James
- Gaeta, Giovanni B.
- Garcia-Samaniego, Javier
- Genov, Jordan
- Gheorghe, Liliana S.
- Gholam, Pierre M.
- Gish, Robert G.
- Glenn, Jeffrey
- Goldis, Adrian
- Hamid, Saeed S.
- Hercun, Julian
- Hsu, Yao-Chun
- Hu, Ching-Chih
- Huang, Jee-Fu
- Idilman, Ramazan
- Jafri, Wasim S. M.
- Janjua, Naveed
- Jelev, Deian
- Jerkeman, Anna
- Jia, Jidong
- Kaberg, Martin
- Kaita, Kelly D. E.
- Kao, Jia-Horng
- Khan, Aamir G.
- Kim, Do Young
- Kondili, Loreta A.
- Lagging, Martin
- Lampertico, Pietro
- Lazaro, Pablo
- Lazarus, V, Jeffrey
- Lee, Mei-Hsuan
- Lim, Young-Suk
- Lobato, Cirley M. O.
- Marinho, Rui T.
- Marotta, Paul J.
- Martins, Alexanda
- Mendes-Correa, Maria Cassia
- Mendez-Sanchez, Nahum
- Navas, Maria-Cristina
- Ning, Qing
- Ormeci, Necati
- Orrego, Mauricio
- Osiowy, Carla
- Pan, Calvin Q.
- Pessoa, Mario G.
- Piracha, Zahra Z.
- Pop, Cora
- Ramos, Jose A. Presa
- Qureshi, Huma
- Raimondo, Giovanni
- Ramji, Alnoor
- Razavi-Shearer, Kathryn
- Ribeiro, Sofia
- Rios-Hincapie, Cielo Y.
- Rodriguez, Manuel
- Rosenberg, William M. C.
- Roulot, Dominique
- Ryder, Stephen D.
- Saeed, Umar
- Safadi, Rifaat
- Sanai, Faisal M.
- Sanchez-Avila, Juan F.
- Santantonio, Teresa A.
- Sarrazin, Christoph
- Seto, Wai-Kay
- Shouval, Daniel
- Simonova, Marieta Y.
- Tanaka, Junko
- Tergast, Tammo L.
- Tsendsuren, Oyunsuren
- Valente, Cristina
- Villalobos-Salcedo, Juan Miguel
- Voeller, Alexis S.
- Waheed, Yasir
- Wong, Grace L-H
- Wong, Vincent W-S
- Wu, Jaw-Ching
- Yang, I, Hwai-
- Yip, Terry C-F
- Yu, Ming-Lung
- Yuen, Man-Fung
- Yurdaydin, Cihan
- Zuckerman, Eli
- Razavi, Homie A.
Unidades de investigação
Abstract
Background & Aims: Hepatitis delta virus (HDV) is a satellite RNA virus that requires the hepatitis B virus (HBV) for assembly and propagation. Individuals infected with HDV progress to advanced liver disease faster than HBV-monoinfected individuals. Recent studies have estimated the global prevalence of anti-HDV antibodies among the HBV-infected population to be 5-15%. This study aimed to better understand HDV prevalence at the population level in 25 countries/territories. Methods: We conducted a literature review to determine the prevalence of anti-HDV and HDV RNA in hepatitis B surface antigen (HBsAg)-positive individuals in 25 countries/territories. Virtual meetings were held with experts from each setting to discuss the findings and collect unpublished data. Data were weighted for patient segments and regional heterogeneity to estimate the prevalence in the HBV-infected population. The findings were then combined with The Polaris Observatory HBV data to estimate the anti-HDV and HDV RNA prevalence in each country/territory at the population level. Results: After adjusting for geographical distribution, disease stage and special populations, the anti-HDV prevalence among the HBsAg+ population changed from the literature estimate in 19 countries. The highest anti-HDV prevalence was 60.1% in Mongolia. Once adjusted for the size of the HBsAg+ population and HDV RNA positivity rate, China had the highest absolute number of HDV RNA+ cases. Conclusions: We found substantially lower HDV prevalence than previously reported, as prior meta-analyses primarily focused on studies conducted in groups/regions that have a higher probability of HBV infection: tertiary care centers, specific risk groups or geographical regions. There is large uncertainty in HDV prevalence estimates. The implementation of reflex testing would improve estimates, while also allowing earlier linkage to care for HDV RNA+ individuals. The logistical and economic burden of reflex testing on the health system would be limited, as only HBsAg+ cases would be screened.
Dados da publicação
- ISSN/ISSNe:
- 1600-0641, 0168-8278
- Tipo:
- Article
- Páginas:
- 232-242
- Link para outro recurso:
- www.scopus.com
Journal of Hepatology Elsevier
Citações Recebidas na Web of Science: 20
Citações Recebidas na Scopus: 21
Documentos
- Não há documentos
Filiações
Keywords
- NUTRITION EXAMINATION SURVEY; B-VIRUS; RISK-FACTORS; NATIONAL-HEALTH; DRUG-USERS; INFECTION; SEROPREVALENCE; EPIDEMIOLOGY; ANTIBODY
Proyectos asociados
The contribution of endoscopic ultrasound and biomarkers in the management of pancreatic adenocarcinoma and its precursor lesions.
Investigador Principal: Manuel Guilherme Gonçalves Macedo
Estudo Clínico Académico . 2023
Noninvasive serum biomarkers of portal hypertension in liver cirrhosis
Investigador Principal: Manuel Guilherme Gonçalves Macedo
Estudo Clínico Académico . 2023
Otimização do rendimento da colangiopancreatografia retrógrada endoscópica na avaliação das estenoses pancreato-biliares indeterminadas
Investigador Principal: Manuel Guilherme Gonçalves Macedo
Estudo Clínico Académico . 2023
Endoscopic Treatment Of Upper Gastrointestinal Postsurgical Leaks
Investigador Principal: Manuel Guilherme Gonçalves Macedo
Estudo Clínico Académico . 2023
Citar a publicação
Razavi DM,Buti M,Tacke F,Terrault NA,Zeuzem S,Abbas Z,Aghemo A,Akarca US,Al Masri NM,Alalwan AM,Blome MA,Aleman S,Alghamdi AS,Alghamdi M,Alghamdi S,Al WK,Ali E,Aljumah AA,Altraif IH,Amarsanaa J,Asselah T,Baatarkhuu O,Babameto A,Ben Z,Berg T,Biondi MJ,Braga WSM,Brandao CE,JR,S,Brunetto MR,Cabezas J,Cardoso M,Chan HLY,Cheinquer H,Chen C,Chen P,Chien C,Child H,Chuang W,Garza LEC,Coco B,Coffin CS,Coppola N,Cornberg M,Craxi A,Crespo J,Cuko L,De Ledinghen V,Duberg A,Etzion O,Ferraz MLG,Ferreira PRA,Forns X,Foster GR,Fung J,Gaeta GB,Garcia J,Genov J,Gheorghe LS,Gholam PM,Gish RG,Glenn J,Goldis A,Hamid SS,Hercun J,Hsu Y,Hu C,Huang J,Idilman R,Jafri WSM,Janjua N,Jelev D,Jerkeman A,Jia J,Kaberg M,Kaita KDE,Kao J,Khan AG,Kim DY,Kondili LA,Lagging M,Lampertico P,Lazaro P,V,,Lee M,Lim Y,Lobato CMO,Macedo G,Marinho RT,Marotta PJ,Martins A,Mendes MC,Mendez N,Navas M,Ning Q,Ormeci N,Orrego M,Osiowy C,Pan CQ,Pessoa MG,Piracha ZZ,Pop C,Ramos JP,Qureshi H,Raimondo G,Ramji A,Razavi K,Ribeiro S,Rios CY,Rodriguez M,Rosenberg WMC,Roulot D,Ryder SD,Saeed U,Safadi R,Sanai FM,Sanchez JF,Santantonio TA,Sarrazin C,Seto W,Shouval D,Simonova MY,Tanaka J,Tergast TL,Tsendsuren O,Valente C,Villalobos JM,Voeller AS,Waheed Y,Wong GL-H,Wong VW-S,Wu J,H,Yip TC-F,Yu M,Yuen M,Yurdaydin C,Zuckerman E,Razavi HA. Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories. J. Hepatol. 2024. 80. (2):p. 232-242. IF:25,700. (1).
