Portal de investigação
Higher frequency of gastric neoplasia in advanced chronic liver disease patients: Impact of screening endoscopy in an intermediate-high risk country
Autores da FMUP
Participantes de fora da FMUP
- Morais R.
- Moreira J.
- Gaspar R.
- Santos-Antunes J.
- Marques M.
- Coelho R.
- Alves R.
- Ferreira-Silva J.
- Dias E.
- Pereira P.
- Lopes S.
- Cardoso H.
- Faria-Ramos I.
- Gullo I.
- Carneiro F.
- Liberal R.
- Macedo G.
Unidades de investigação
Abstract
Background: The Baveno VII guidelines were proposed to identify which patients could safely avoid screening esophagogastroduodenoscopy (EGD) for gastroesophageal varices. We aimed to evaluate the frequency of gastric neoplasia in compensated advanced chronic liver disease (cACLD) patients who underwent EGD for screening of gastroesophageal varices (GOEV) compared to a healthy population. Methods: Retrospective study that enrolled all cACLD patients who underwent EGD for GOEV screening (January 2008-June 2018) in a tertiary reference center. cACLD patients were compared with asymptomatic healthy individuals who underwent EGD in a private hospital setting (April 2017-March 2018). Results: We evaluated 1845 patients (481 cACLD patients, 1364 healthy individuals). A significantly higher frequency of gastric neoplasia was observed in patients with cACLD compared to healthy individuals (4.0% vs. 1.0 %; p < 0.001). Rare histopathological subtypes (WHO Classification) accounted for 28.7 % of gastric carcinoma cases in the cACLD cohort. Seven cases of gastric neoplasia (36.8 % of gastric neoplasia cases in the cACLD patients) were diagnosed in patients who, according to the Baveno VII criteria, would have not been submitted to EGD. Conclusion: We found an increased frequency of gastric neoplasia in patients with cACLD in comparison with healthy individuals. In countries with intermediate-high risk for GC, continuing to perform EGD could be beneficial. © 2024 Editrice Gastroenterologica Italiana S.r.l.
Dados da publicação
- ISSN/ISSNe:
- 1590-8658, 1878-3562
- Tipo:
- Article
- Páginas:
- 2133-2142
- Link para outro recurso:
- www.scopus.com
Digestive and Liver Disease Elsevier
Documentos
- Não há documentos
Filiações
Keywords
- adult; alcohol consumption; Article; cancer recurrence; cancer screening; chromoendoscopy; chronic liver disease; clinical outcome; cohort analysis; colonoscopy; colorectal cancer; controlled study; disease association; esophagogastroduodenoscopy; esophagus varices; female; follow up; gastritis; gastrointestinal endoscopy; Helicobacter infection; histopathology; human; human tissue; intestinal metaplasia; Kaplan Meier method; liver biopsy; liver cell carcinoma; logistic regression analysis; major clinical study; male; medical record review; middle aged; outpatient department; overall survival; precancer; retrospective study; smoking; stomach adenocarcinoma; stomach atrophy; stomach cancer; transient elastography; varicosis
Proyectos asociados
Seroprevalence of SARS-CoV-2 and assessment of epidemiologic determinants in Portuguese municipal workers
Investigador Principal: Bernardo Manuel De Sousa Pinto
Estudo Clínico Académico (SARS-CoV-2) . 2021
Citar a publicação
Morais R,Moreira J,Gaspar R,Santos J,Marques M,Coelho R,Alves R,Ferreira J,Dias E,Pereira P,Lopes S,Cardoso H,Sousa B,Faria I,Gullo I,Carneiro F,Liberal R,Macedo G. Higher frequency of gastric neoplasia in advanced chronic liver disease patients: Impact of screening endoscopy in an intermediate-high risk country. Dig. Liver Dis. 2024. 56. (12):p. 2133-2142. IF:4,500. (2).
