Portal de investigação
The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Freitas, Claudia
- Sousa, Catarina
- Machado, Francisco
- Serino, Mariana
- Santos, Vanessa
- Cruz-Martins, Natalia
- Teixeira, Armando
- Cunha, Antonio
- Pereira, Tania
- Oliveira, Helder P.
- Costa, Jose Luis
Unidades de investigação
Abstract
Liquid biopsy is an emerging technology with a potential role in the screening and early detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and are currently under ongoing investigation. In this article, we review the available data on the use of circulating biomarkers for the early detection of lung cancer, focusing on the circulating tumor cells, circulating cell-free DNA, circulating micro-RNAs, tumor-derived exosomes, and tumor-educated platelets, providing an overview of future potential applicability in the clinical practice. While several biomarkers have shown exciting results, diagnostic performance and clinical applicability is still limited. The combination of different biomarkers, as well as their combination with other diagnostic tools show great promise, although further research is still required to define and validate the role of liquid biopsies in clinical practice.
Dados da publicação
- ISSN/ISSNe:
- 2234-943X, 2234-943X
- Tipo:
- Review
- Páginas:
- -
- PubMed:
- 33937034
- Link para outro recurso:
- www.scopus.com
Frontiers in Oncology Frontiers Media S.A.
Citações Recebidas na Web of Science: 66
Citações Recebidas na Scopus: 69
Documentos
- Não há documentos
Filiações
Keywords
- lung cancer; clinical biomarkers detection; liquid biopsy; cell-free DNA; exosomes; tumor-educated platelets; circulating tumor associated cells
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Citar a publicação
Freitas C,Sousa C,Machado F,Serino M,Santos V,Cruz N,Teixeira A,Cunha A,Pereira T,Oliveira HP,Costa JL,Hespanhol V. The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer. Front. Oncol. 2021. 11634316. IF:5,738. (2).
