Portal de investigação
Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Bäck M.
- Xhaard C.
- Rouget R.
- Thuillier Q.
- Plunde O.
- Larsson S.C.
- Girerd N.
- Boivin J.-M.
- Bozec E.
- Mercklé L.
- Zannad F.
- Hoge A.
- Guillaume M.
- Dandine-Roulland C.
- Le Floch E.
- Bacq-Daian D.
- Deleuze J.-F.
- Van den Berghe L.
- Nazare J.-A.
- Laville M.
- Branlant C.
- Behm-Ansmant I.
- Wagner S.
- Rossignol P.
Unidades de investigação
Abstract
Aims Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remain controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determine PUFA levels. Increased arterial stiffness represents an independent predictor of mortality and cardiovascular events. The aim of the present study was to determine the association of PUFA intake, FADS1 genotype, and FADS expression with arterial stiffness. Methods and results A cross-sectional population-based cohort study of 1464 participants without overt cardiovascular disease was conducted. Dietary intake was assessed using a food frequency questionnaire. Arterial stiffness was assessed by carotid–femoral pulse wave velocity (cfPWV), and the FADS1 locus variant was determined. Blood cell transcriptomics was performed in a subset of 410 individuals. Pulse wave velocity was significantly associated with the FADS1 locus variant. Differential associations between PWV and omega-3 PUFA intake were observed depending on the FADS1 genotype. High omega-3 PUFA intake attenuated the FADS1 genotype-dependent associations. Carriers of the minor FADS1 locus variant exhibited increased expression of FADS2, which is associated with PWV. Conclusion Taken together, these findings point to FADS1 genotype-dependent associations of omega-3 PUFA intake on subclinical cardiovascular disease. These findings may have implications for identifying responders and non-responders to omega-3 PUFA supplementation and open up for personalized dietary counselling in cardiovascular prevention. © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology.
Dados da publicação
- ISSN/ISSNe:
- 2752-4191,
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 35919123
- Link para outro recurso:
- www.scopus.com
European Heart Journal Open Oxford University Press
Citações Recebidas na Web of Science: 4
Citações Recebidas na Scopus: 13
Documentos
- Não há documentos
Filiações
Keywords
- Arterial stiffness; Dietary; Inflammation; Omega-3 fatty acids; Prevention; STANISLAS cohort
Financiamento
Projetos associados
Dapagliflozin, Spironolactone or Both for HFpEF (SOGALDI-PEF) - NCT05676684
Investigador Principal: João Pedro Melo Marques Pinho Ferreira
Ensaio Clínico Académico (SOGALDI-PEF) . AstraZeneca . 2022
