A Case of Acute Eosinophilic Pneumonia Associated With Non-steroidal Antiinflammatory Drugs

Autores da FMUP

• Andreia Sofia Costa Teixeira

  Autor

• Célia Da Conceição Duarte Cruz

  Autor

Participantes de fora da FMUP

• Ribeiro, Rui
• Lopes, Tania

Unidades de investigação

• Biomedicina

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Medicina da Comunidade, Informação e Decisão em Saúde

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Non -steroidal anti-inflammatory drugs (NSAIDs) are widely used and their gastric, cardiovascular, and renal adverse effects have been well documented. Although rare, NSAID-induced acute eosinophilic pneumonia (AEP) may occur. We report a case of AEP related to naproxen and celecoxib. The patient presented with dry cough and breathlessness two weeks after she started taking these drugs. The chest radiograph displayed bilateral opacities and she had peripheral eosinophilia. Bronchoalveolar lavage was performed at a time when blood eosinophilia was already decreasing and cell analysis revealed 63700 cells/mL with 9% eosinophil. After ruling out other possible etiologies, drug -induced AEP was diagnosed. The patient improved after drug discontinuation. When it comes to drug -induced AEP identifying a causative agent is essential as cessation of the drug is the mainstay of the treatment.

Keywords

• celecoxib; naproxen; eosinophilic pneumonias; non-steroidal antiinflammatory drugs; drug induced eosinophilic pneumonia