Portal de investigação
Second primary cancers among females with a first primary breast cancer: a population-based study in Northern Portugal
Autores da FMUP
Participantes de fora da FMUP
- Goncalves, Elisabete
- Rodrigues, Jessica Rocha
- Calisto, Rita
- Bento, Maria Jose
- Morais, Samantha
Unidades de investigação
Abstract
Purpose To estimate the incidence rate of second primary cancers (SPCs) and the cumulative incidence of metachronous [diagnosed > 2 months after a first primary cancer (FPC)] SPCs in patients with a breast FPC, and to compare the incidence of SPC [overall, synchronous (<= 2 months of the FPC) and metachronous] with that expected in the general female population.Methods A cohort of patients with a breast FPC from the North Region Cancer Registry of Portugal, diagnosed in 2000-2010 (n = 15,981), was followed to 31 December 2015 for synchronous and metachronous SPCs. Cumulative incidence of metachronous SPCs considering death as a competing event, and incidence rates and standardized incidence ratios of SPCs were estimated.Results The diagnosis of an SPC occurred in 1229 (7.7%) of patients with a breast FPC. SPCs occurred mainly in the breast, followed by digestive organs, lung, thyroid, and female genital organs. Globally, patients with a breast FPC had a higher incidence for all types of cancer compared to the general female population, and in particular for cancers of the breast, stomach, colon, lung, lymphoma, uterus, and ovary. The 10-year cumulative incidence of metachronous SPCs following a breast FPC was 6.6% and the corresponding 10-year cumulative mortality was 26.2%.Conclusion In Portugal, patients with a breast FPC have a higher incidence of cancer compared to the general female population, highlighting important aspects of care, surveillance, and counselling among this growing number of patients.
Dados da publicação
- ISSN/ISSNe:
- 0167-6806, 1573-7217
- Tipo:
- Article
- Páginas:
- 367-376
- Link para outro recurso:
- www.scopus.com
Breast Cancer Research and Treatment Springer New York
Citações Recebidas na Web of Science: 3
Citações Recebidas na Scopus: 2
Documentos
- Não há documentos
Filiações
Keywords
- Breast neoplasms; Epidemiology; Population register; Second primary neoplasm
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Citar a publicação
Goncalves E,Fontes F,Rodrigues JR,Calisto R,Bento MJ,Lunet N,Morais S. Second primary cancers among females with a first primary breast cancer: a population-based study in Northern Portugal. Breast Cancer Res. Treat. 2024. 204. (2):p. 367-376. IF:3,800. (2).
