Second primary cancers among females with a first primary breast cancer: a population-based study in Northern Portugal

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Filipa Ferreira Maia Fontes

    Autor

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Goncalves, Elisabete
  • Rodrigues, Jessica Rocha
  • Calisto, Rita
  • Bento, Maria Jose
  • Morais, Samantha

Unidades de investigação

Abstract

Purpose To estimate the incidence rate of second primary cancers (SPCs) and the cumulative incidence of metachronous [diagnosed > 2 months after a first primary cancer (FPC)] SPCs in patients with a breast FPC, and to compare the incidence of SPC [overall, synchronous (<= 2 months of the FPC) and metachronous] with that expected in the general female population.Methods A cohort of patients with a breast FPC from the North Region Cancer Registry of Portugal, diagnosed in 2000-2010 (n = 15,981), was followed to 31 December 2015 for synchronous and metachronous SPCs. Cumulative incidence of metachronous SPCs considering death as a competing event, and incidence rates and standardized incidence ratios of SPCs were estimated.Results The diagnosis of an SPC occurred in 1229 (7.7%) of patients with a breast FPC. SPCs occurred mainly in the breast, followed by digestive organs, lung, thyroid, and female genital organs. Globally, patients with a breast FPC had a higher incidence for all types of cancer compared to the general female population, and in particular for cancers of the breast, stomach, colon, lung, lymphoma, uterus, and ovary. The 10-year cumulative incidence of metachronous SPCs following a breast FPC was 6.6% and the corresponding 10-year cumulative mortality was 26.2%.Conclusion In Portugal, patients with a breast FPC have a higher incidence of cancer compared to the general female population, highlighting important aspects of care, surveillance, and counselling among this growing number of patients.

Dados da publicação

ISSN/ISSNe:
0167-6806, 1573-7217

Breast Cancer Research and Treatment  Springer New York

Tipo:
Article
Páginas:
367-376
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 3

Citações Recebidas na Scopus: 2

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Keywords

  • Breast neoplasms; Epidemiology; Population register; Second primary neoplasm

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