Portal de investigação
Aspirin but not statins is inversely related to gastric cancer with a duration-risk effect: Results from the Stomach Cancer Pooling Project Consortium
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Pastorino, Roberta
- Marafon, Denise Pires
- Sassano, Michele
- Hoxhaj, Ilda
- Pelucchi, Claudio
- Liao, Linda M.
- Rabkin, Charles S.
- Sinha, Rashmi
- Morais, Samantha
- Zaridze, David
- Maximovich, Dmitry
- Aragones, Nuria
- Castano-Vinyals, Gemma
- Gomez-Acebo, Ines
- Lopez-Carrillo, Lizbeth
- Lopez-Cervantes, Malaquias
- Bonzi, Rossella
- Turati, Federica
- Boffetta, Paolo
- Camargo, Maria Constanza
- Curado, Maria Paula
- Vioque, Jesus
- Zhang, Zuo-Feng
- Negri, Eva
- La Vecchia, Carlo
- Boccia, Stefania
Unidades de investigação
Abstract
BackgroundAspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC.MethodsA pooled analysis of seven case-control studies within the Stomach Cancer Pooling Project, including 3220 cases and 9752 controls, was conducted. Two-stage modeling analyses were used to estimate the association between aspirin and statin use and GC after adjusting for potential confounders.ResultsThe pooled odds ratio (OR) of GC for aspirin users versus nonusers was 0.72 (95% confidence interval [CI], 0.54-0.95). The protective effect of aspirin appeared stronger in individuals without a GC family history (OR, 0.60; 95% CI, 0.37-0.95), albeit with borderline heterogeneity between those with and without a family history (p = .064). The OR of GC decreased with increasing duration of aspirin use, with an OR of 0.41 (95% CI, 0.18-0.95) for durations of >= 15 years. An inverse, nonsignificant association with the risk of GC was observed for the use of statins alone (OR, 0.79; 95% CI, 0.52-1.18).ConclusionsThese findings suggest that aspirin use, particularly long-term use, is associated with a reduced risk of GC, whereas a similar association was not observed with statins, possibly because of the low frequency of use. Aspirin use, particularly long-term use, is associated with a reduced risk of gastric cancer.In this study, statin use was not significantly associated with gastric cancer risk in the populations studied, possibly because of the low frequency of use, which resulted in limited statistical power.
Dados da publicação
- ISSN/ISSNe:
- 0008-543X, 1097-0142
- Tipo:
- Article
- Páginas:
- 4276-4286
- DOI:
- 10.1002/cncr.35510
- Link para outro recurso:
- www.scopus.com
Cancer John Wiley & Sons Inc.
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 1
Documentos
- Não há documentos
Filiações
Keywords
- aspirin; epidemiological study; gastric cancer; statins
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Citar a publicação
Pastorino R,Marafon DP,Sassano M,Hoxhaj I,Pelucchi C,Liao LM,Rabkin CS,Sinha R,Lunet N,Morais S,Zaridze D,Maximovich D,Aragones N,Castano G,Gomez I,Lopez L,Lopez M,Bonzi R,Turati F,Boffetta P,Camargo MC,Curado MP,Vioque J,Zhang Z,Negri E,La Vecchia C,Boccia S. Aspirin but not statins is inversely related to gastric cancer with a duration-risk effect: Results from the Stomach Cancer Pooling Project Consortium. Cancer. 2024. 130. (24):p. 4276-4286. IF:6,200. (1).
