Aspirin but not statins is inversely related to gastric cancer with a duration-risk effect: Results from the Stomach Cancer Pooling Project Consortium

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Pastorino, Roberta
  • Marafon, Denise Pires
  • Sassano, Michele
  • Hoxhaj, Ilda
  • Pelucchi, Claudio
  • Liao, Linda M.
  • Rabkin, Charles S.
  • Sinha, Rashmi
  • Morais, Samantha
  • Zaridze, David
  • Maximovich, Dmitry
  • Aragones, Nuria
  • Castano-Vinyals, Gemma
  • Gomez-Acebo, Ines
  • Lopez-Carrillo, Lizbeth
  • Lopez-Cervantes, Malaquias
  • Bonzi, Rossella
  • Turati, Federica
  • Boffetta, Paolo
  • Camargo, Maria Constanza
  • Curado, Maria Paula
  • Vioque, Jesus
  • Zhang, Zuo-Feng
  • Negri, Eva
  • La Vecchia, Carlo
  • Boccia, Stefania

Unidades de investigação

Abstract

BackgroundAspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC.MethodsA pooled analysis of seven case-control studies within the Stomach Cancer Pooling Project, including 3220 cases and 9752 controls, was conducted. Two-stage modeling analyses were used to estimate the association between aspirin and statin use and GC after adjusting for potential confounders.ResultsThe pooled odds ratio (OR) of GC for aspirin users versus nonusers was 0.72 (95% confidence interval [CI], 0.54-0.95). The protective effect of aspirin appeared stronger in individuals without a GC family history (OR, 0.60; 95% CI, 0.37-0.95), albeit with borderline heterogeneity between those with and without a family history (p = .064). The OR of GC decreased with increasing duration of aspirin use, with an OR of 0.41 (95% CI, 0.18-0.95) for durations of >= 15 years. An inverse, nonsignificant association with the risk of GC was observed for the use of statins alone (OR, 0.79; 95% CI, 0.52-1.18).ConclusionsThese findings suggest that aspirin use, particularly long-term use, is associated with a reduced risk of GC, whereas a similar association was not observed with statins, possibly because of the low frequency of use. Aspirin use, particularly long-term use, is associated with a reduced risk of gastric cancer.In this study, statin use was not significantly associated with gastric cancer risk in the populations studied, possibly because of the low frequency of use, which resulted in limited statistical power.

Dados da publicação

ISSN/ISSNe:
0008-543X, 1097-0142

Cancer  John Wiley & Sons Inc.

Tipo:
Article
Páginas:
4276-4286
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 1

Citações Recebidas na Scopus: 1

Documentos

  • Não há documentos

Métricas

Filiações mostrar / ocultar

Keywords

  • aspirin; epidemiological study; gastric cancer; statins

Proyectos asociados

Breast cancer heterogeneity - etiology, clinical management, use of health resources and survival

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2022

Longitudinal Assessment of Cognitive Decline in Breast and Prostate Cancer Survivors

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico (Cognitive Decline) . 2022

Healthcare use among cancer patients and their partners in different phases of the cancer pathway

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2021

Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

Citar a publicação

Partilhar a publicação