The protective effect of dietary folate intake on gastric cancer is modified by alcohol consumption: A pooled analysis of the StoP Consortium

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Gonzalez-Palacios, Sandra
  • Compan-Gabucio, Laura-Maria
  • Torres-Collado, Laura
  • Oncina-Canovas, Alejandro
  • Garcia-de-la-Hera, Manuela
  • Collatuzzo, Giulia
  • Negri, Eva
  • Pelucchi, Claudio
  • Rota, Matteo
  • Lopez-Carrillo, Lizbeth
  • Morais, Samantha
  • Ward, Mary H.
  • Martin, Vicente
  • Lozano-Lorca, Macarena
  • Malekzadeh, Reza
  • Pakseresht, Mohammadreza
  • Hernandez-Ramirez, Raul Ulises
  • Bonzi, Rossella
  • Patel, Linia
  • Lopez-Cervantes, Malaquias
  • Rabkin, Charles S.
  • Tsugane, Shoichiro
  • Hidaka, Akihisa
  • Trichopoulou, Antonia
  • Karakatsani, Anna
  • Camargo, M. Constanza
  • Curado, Maria Paula
  • Zhang, Zuo-Feng
  • La Vecchia, Carlo
  • Boffetta, Paolo
  • Vioque, Jesus

Unidades de investigação

Abstract

Dietary folate intake has been identified as a potentially modifiable factor of gastric cancer (GC) risk, although the evidence is still inconsistent. We evaluate the association between dietary folate intake and the risk of GC as well as the potential modification effect of alcohol consumption. We pooled data for 2829 histologically confirmed GC cases and 8141 controls from 11 case-control studies from the international Stomach Cancer Pooling Consortium. Dietary folate intake was estimated using food frequency questionnaires. We used linear mixed models with random intercepts for each study to calculate adjusted odds ratios (OR) and 95% confidence interval (CI). Higher folate intake was associated with a lower risk of GC, although this association was not observed among participants who consumed >2.0 alcoholic drinks/day. The OR for the highest quartile of folate intake, compared with the lowest quartile, was 0.78 (95% CI, 0.67-0.90, P-trend = 0.0002). The OR per each quartile increment was 0.92 (95% CI, 0.87-0.96) and, per every 100 mu g/day of folate intake, was 0.89 (95% CI, 0.84-0.95). There was a significant interaction between folate intake and alcohol consumption (P-interaction = 0.02). The lower risk of GC associated with higher folate intake was not observed in participants who consumed >2.0 drinks per day, ORQ4v Q1 = 1.15 (95% CI, 0.85-1.56), and the OR100 mu g/day = 1.02 (95% CI, 0.92-1.15). Our study supports a beneficial effect of folate intake on GC risk, although the consumption of >2.0 alcoholic drinks/day counteracts this beneficial effect.

Dados da publicação

ISSN/ISSNe:
0020-7136, 1097-0215

International Journal of Cancer  Wiley-Liss Inc.

Tipo:
Article
Páginas:
1367-1375
Link para outro recurso:
www.scopus.com

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Keywords

  • alcohol consumption; dietary folate; gastric cancer; interaction

Proyectos asociados

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Longitudinal Assessment of Cognitive Decline in Breast and Prostate Cancer Survivors

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Estudo Clínico Académico (Cognitive Decline) . 2022

Healthcare use among cancer patients and their partners in different phases of the cancer pathway

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Estudo Clínico Académico . 2021

Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

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Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

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Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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