Portal de investigação
The protective effect of dietary folate intake on gastric cancer is modified by alcohol consumption: A pooled analysis of the StoP Consortium
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Gonzalez-Palacios, Sandra
- Compan-Gabucio, Laura-Maria
- Torres-Collado, Laura
- Oncina-Canovas, Alejandro
- Garcia-de-la-Hera, Manuela
- Collatuzzo, Giulia
- Negri, Eva
- Pelucchi, Claudio
- Rota, Matteo
- Lopez-Carrillo, Lizbeth
- Morais, Samantha
- Ward, Mary H.
- Martin, Vicente
- Lozano-Lorca, Macarena
- Malekzadeh, Reza
- Pakseresht, Mohammadreza
- Hernandez-Ramirez, Raul Ulises
- Bonzi, Rossella
- Patel, Linia
- Lopez-Cervantes, Malaquias
- Rabkin, Charles S.
- Tsugane, Shoichiro
- Hidaka, Akihisa
- Trichopoulou, Antonia
- Karakatsani, Anna
- Camargo, M. Constanza
- Curado, Maria Paula
- Zhang, Zuo-Feng
- La Vecchia, Carlo
- Boffetta, Paolo
- Vioque, Jesus
Unidades de investigação
Abstract
Dietary folate intake has been identified as a potentially modifiable factor of gastric cancer (GC) risk, although the evidence is still inconsistent. We evaluate the association between dietary folate intake and the risk of GC as well as the potential modification effect of alcohol consumption. We pooled data for 2829 histologically confirmed GC cases and 8141 controls from 11 case-control studies from the international Stomach Cancer Pooling Consortium. Dietary folate intake was estimated using food frequency questionnaires. We used linear mixed models with random intercepts for each study to calculate adjusted odds ratios (OR) and 95% confidence interval (CI). Higher folate intake was associated with a lower risk of GC, although this association was not observed among participants who consumed >2.0 alcoholic drinks/day. The OR for the highest quartile of folate intake, compared with the lowest quartile, was 0.78 (95% CI, 0.67-0.90, P-trend = 0.0002). The OR per each quartile increment was 0.92 (95% CI, 0.87-0.96) and, per every 100 mu g/day of folate intake, was 0.89 (95% CI, 0.84-0.95). There was a significant interaction between folate intake and alcohol consumption (P-interaction = 0.02). The lower risk of GC associated with higher folate intake was not observed in participants who consumed >2.0 drinks per day, ORQ4v Q1 = 1.15 (95% CI, 0.85-1.56), and the OR100 mu g/day = 1.02 (95% CI, 0.92-1.15). Our study supports a beneficial effect of folate intake on GC risk, although the consumption of >2.0 alcoholic drinks/day counteracts this beneficial effect.
Dados da publicação
- ISSN/ISSNe:
- 0020-7136, 1097-0215
- Tipo:
- Article
- Páginas:
- 1367-1375
- DOI:
- 10.1002/ijc.35004
- Link para outro recurso:
- www.scopus.com
International Journal of Cancer Wiley-Liss Inc.
Documentos
- Não há documentos
Filiações
Keywords
- alcohol consumption; dietary folate; gastric cancer; interaction
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Citar a publicação
Gonzalez S,Compan L,Torres L,Oncina A,Garcia M,Collatuzzo G,Negri E,Pelucchi C,Rota M,Lopez L,Lunet N,Morais S,Ward MH,Martin V,Lozano M,Malekzadeh R,Pakseresht M,Hernandez RU,Bonzi R,Patel L,Lopez M,Rabkin CS,Tsugane S,Hidaka A,Trichopoulou A,Karakatsani A,Camargo MC,Curado MP,Zhang Z,La Vecchia C,Boffetta P,Vioque J. The protective effect of dietary folate intake on gastric cancer is modified by alcohol consumption: A pooled analysis of the StoP Consortium. Int. J. Cancer. 2024. 155. (8):p. 1367-1375. IF:6,400. (1).
