Prediabetes remission after bariatric surgery: a 4-years follow-up study

Data de publicação: 01/01/2024

Autores da FMUP

João Sérgio De Lima Soares Neves

Autor
Catarina Afonso Couto E Vale

Autor
Jorge Manuel P. Pires Pedro

Autor
Selma Maria Barbosa Souto

Autor
Davide Maurício Costa Carvalho

Autor
Hugo Miguel Teixeira Ferraz Santos Sousa

Autor
André Manuel Costa Pinho

Autor
Marta João Rodrigues Da Silva

Autor

Participantes de fora da FMUP

Canha, M.
Silva, MM
Mendonca, F
Moreno, T
Ribeiro, S
Goncalves, J
Ferreira, HU
Gil-Santos, S
Calheiros, R
Meira, I
Menino, J
Gon?alves, V.
Varela, A.
da Costa, EL
Sim?es Freitas, P.
Preto, J.
Galego, CCORT
Correia, MFFSC
Gil, CFC
Melim, DBF
Pinto, E.
Martins, CSP
Pereira, LMG
Magalhaes, IVS
Brand?o, I.
Andrade, SMF
Nunes, PML

Unidades de investigação

Cirurgia e Fisiologia
Ginecologia-Obstetrícia e Pediatria
Laboratório Associado RISE- Rede de Investigação em Saúde

Investigador

Fernando Carlos De Landér Schmitt
Medicina
RISE-Health

Investigador

Fernando Carlos De Landér Schmitt

Abstract

BackgroundBariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce. We aimed to assess prediabetes remission rate and clinical predictors of remission in a 4 year follow up period.MethodsObservational longitudinal study including patients with obesity and prediabetes who had undergone bariatric surgery in our centre. Prediabetes was defined as having a baseline glycated haemoglobin (A1c) between 5.7% and 6.4% and absence of anti-diabetic drug treatment. We used logistic regression models to evaluate the association between the predictors and prediabetes remission rate.ResultsA total of 669 patients were included, 84% being female. The population had a mean age of 45.4 +/- 10.1 years-old, body mass index of 43.8 +/- 5.7 kg/m2, and median A1c of 5.9 [5.8, 6.1]%. After bariatric surgery, prediabetes remission rate was 82%, 73%, 66%, and 58%, respectively in the 1st, 2nd, 3rd, and 4th years of follow-up. Gastric sleeve (GS) surgery was associated with higher prediabetes remission rate than Roux-en-Y gastric bypass surgery in the 3rd year of follow-up. Men had a higher remission rate than women, in the 1st and 3nd years of follow-up in the unadjusted analysis. Younger patients presented a higher remission rate comparing to older patients in the 3rd year of follow-up.ConclusionWe showed a high prediabetes remission rate after bariatric surgery. The remission rate decreases over the follow-up period, although most of the patients maintain the normoglycemia. Prediabetes remission seems to be more significant in patients who had undergone GS, in male and in younger patients.