A Common Variant in the CDK8 Gene Is Associated with Sporadic Pituitary Adenomas in the Portuguese Population: A Case-Control Study

Autores da FMUP

• Davide Maurício Costa Carvalho

  Autor

Participantes de fora da FMUP

• Gaspar, LM
• Goncalves, CI
• Fonseca, F
• Cortez, L
• Palha, A
• Barros, IF
• Nobre, E
• Duarte, JS
• Amaral, C
• Bugalho, MJ
• Marques, O
• Pereira, BD
• Lemos, MC

Unidades de investigação

• Medicina

Abstract

The majority of pituitary adenomas occur in a sporadic context, and in the absence of known genetic predisposition. Three common variants at the NEBL (rs2359536), PCDH15 (rs10763170) and CDK8 (rs17083838) loci were previously associated with sporadic pituitary adenomas in the Han Chinese population, but these findings have not yet been replicated in any other population. The aim of this case-control study was to assess if these variants are associated with susceptibility to sporadic pituitary adenomas in the Portuguese population. Genotype and allele frequencies were determined in 570 cases and in 546 controls. The CDK8 rs17083838 minor allele (A allele) was significantly associated with sporadic pituitary adenomas, under an additive (odds ratio (OR) 1.73, 95% confidence interval (CI) 1.19-2.50, p = 0.004) and dominant (OR 1.82, 95% CI 1.24-2.68, p = 0.002) inheritance model. The NEBL rs2359536 and PCDH15 rs10763170 variants were not associated with the overall risk for the disease, although a borderline significant association was observed between the PCDH15 rs10763170 minor allele (T allele) and somatotrophinomas (dominant model, OR 1.55, 95% CI 1.02-2.35, p = 0.035). These findings suggest that the CDK8 rs17083838 variant, and possibly the PCDH15 rs10763170 variant, may increase susceptibility to sporadic pituitary adenomas in the Portuguese population.

Keywords

• pituitary adenoma; NEBL; nebulette; PCDH15; protocadherin-related 15; CDK8; cyclin dependent kinase 8; SNP; single nucleotide polymorphism; genetic susceptibility