Acute Myocardial Infarction with Non-Obstructive Coronary Arteries ? Stratifying the Risk of a ?new? Clinical Entity using an ?Old? Tool

Data de publicação:

Autores da FMUP

  • Davide Maurício Costa Carvalho

    Autor

Participantes de fora da FMUP

  • Ca?oilo, M
  • Afreixo, V
  • Bastos, JM
  • Ferraz, L
  • Vieira, M
  • Santos, L
  • Gonzaga, A
  • Ferreira, R
  • Adrega, T
  • Faustino, A
  • Briosa, A

Unidades de investigação

Abstract

Background: Some of the patients admitted for acute myocardial infarction have non-obstructive coronary artery disease (MINOCA). Their prognosis is not always benign, making it necessary the development of tools for risk stratification of these patients. Objectives: To describe the characteristics of a sample of patients admitted for suspected MINOCA and to evaluate the prognostic value of GRACE score in this population. Methods: This was a retrospective, observational, single-center, cohort study involving 56 consecutive patients with MINOCA. During one-year follow-up, patients were assessed for mortality and major adverse cardiovascular events (MACE) ? a composite of all-cause mortality and hospitalization due to acute myocardial infarction, heart failure, ischemic stroke, and acute limb ischemia. Statistical analysis was performed using a non-parametric approach, with the Mann-Whitney U test for quantitative variables and ROC curves for assessing the discriminatory power of the Grace score in predicting cardiovascular events. The level of significance was set at 5%. Results: Of the 56 MINOCA patients included in the study (median age 67 years), 55.4% were female. During the one-year follow-up, mortality rate was 5.5% and 9.1% of patients had MACE. A higher GRACE score was associated with mortality (p = 0.019; AUC 0.907; 95%CI 0.812?1.000; cut off 138) and MACE (p =0.034; AUC 0.790; 95%CI 0.632?0.948; cutoff 114). Conclusion: The definition of MINOCA includes various diagnoses and prognoses, and the GRACE score is useful for risk stratification of patients with this condition. ? 2021, Sociedade Brasileira de Cardiologia. All rights reserved.

Dados da publicação

ISSN/ISSNe:
2359-4802,

International Journal Of Cardiovascular Sciences  Sociedade Brasileira de Cardiologia

Tipo:
Article
Páginas:
1-

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Proyectos asociados

Diabetic Neuropathy, Central Nervous System Plasticity and Metabolic Disfunction

Investigador Principal: Davide Maurício Costa Carvalho

Estudo Clínico Académico . 2020

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