Pharmacogenetic Approaches in Personalized Medicine for Postoperative Pain Management

Autores da FMUP

• Daniel Humberto Pozza

  Autor

Participantes de fora da FMUP

• do Couto, MLF
• Fonseca, S

Unidades de investigação

• Biomedicina

Abstract

Despite technical and pharmacological advancements in recent years, including optimized therapies and personalized medicine, postoperative pain management remains challenging and sometimes undertreated. This review aims to summarize and update how genotype-guided therapeutics within personalized medicine can enhance postoperative pain management. Several studies in the area have demonstrated that genotype-guided therapy has the ability to lower opioid consumption and improve postoperative pain. Gene mutations, primarily OPRM1, CYP2D6, CYP2C9, COMT and ABCB1, have been shown to exert nuanced influences on analgesic response and related pharmacological outcomes. This review underscores the integration of pharmacogenetic-guided personalized medicine into perioperative care, particularly when there is uncertainty regarding opioid prescriptions. This approach leads to superior outcomes in terms of postoperative pain relief and reduced morbidity for numerous patients.

Keywords

• pharmacogenetics; personalized medicine; postoperative pain; pain management; drug response; genetic markers; therapeutic efficacy