Pharmacogenetic Approaches in Personalized Medicine for Postoperative Pain Management

Autores da FMUP
Participantes de fora da FMUP
- do Couto, MLF
- Fonseca, S
Unidades de investigação
Abstract
Despite technical and pharmacological advancements in recent years, including optimized therapies and personalized medicine, postoperative pain management remains challenging and sometimes undertreated. This review aims to summarize and update how genotype-guided therapeutics within personalized medicine can enhance postoperative pain management. Several studies in the area have demonstrated that genotype-guided therapy has the ability to lower opioid consumption and improve postoperative pain. Gene mutations, primarily OPRM1, CYP2D6, CYP2C9, COMT and ABCB1, have been shown to exert nuanced influences on analgesic response and related pharmacological outcomes. This review underscores the integration of pharmacogenetic-guided personalized medicine into perioperative care, particularly when there is uncertainty regarding opioid prescriptions. This approach leads to superior outcomes in terms of postoperative pain relief and reduced morbidity for numerous patients.
Dados da publicação
- ISSN/ISSNe:
- 2227-9059, 2227-9059
- Tipo:
- Article
- Páginas:
- 729-
- Link para outro recurso:
- www.scopus.com
Biomedicines MDPI AG
Documentos
- Não há documentos
Filiações
Filiações não disponíveis
Keywords
- pharmacogenetics; personalized medicine; postoperative pain; pain management; drug response; genetic markers; therapeutic efficacy
Proyectos asociados
Resultados de um Protocolo QST em voluntários saudáveis e em pacientes com dor crónica: um ensaio clínico controlado
Investigador Principal: Daniel Humberto Pozza
Ensaio Clínico Académico (Dor Crónica) . 2023
Citar a publicação
do MLF,Fonseca S,Pozza D. Pharmacogenetic Approaches in Personalized Medicine for Postoperative Pain Management. Biomedicines. 2024. 12. (4):p. 729-729. IF:4,700. (1).