Portal de investigação
Epidemiology of pediatric parapneumonic pleural effusion during 13-valent pneumococcal conjugate vaccine implementation
Autores da FMUP
Participantes de fora da FMUP
- Moral, Luis
- Toral, Teresa
- Marco, Nuria
- Clavijo, Agustin
- Canals, Francisco
- Fornies, Maria Jose
- Gonzalez, Maria Cristina
- Moral, Jorge
- Marquez, Marta
- Caballero, Maria
- Huertas, Ana Maria
- Garcia-Aviles, Belen
- Belda, Monica
Unidades de investigação
Abstract
Introduction: The reported incidence of parapneumonic pleural effusion, including empyema, has shown fluctuations in the last decades. It has been related to the implementation of different types of conjugate pneumococcal vaccines.Methods: We have retrospectively reviewed data from all 10 public hospitals in Alicante Province (Spain) covering a population of 279,000 children under 15 years of age, between 2010 and 2018. Effusions less than 10 mm (PE-) and those of 10 mm or more (PE+) were separated.Results: A total of 366 episodes of parapneumonic pleural effusion have been analyzed, 178 PE- (48.6%) and 188 PE+ (51.4%), with a median age of 4 years (interquartile range: 2-7 years) and marked seasonality with the maximum in winter and the minimum in summer. A culture proven bacterial agent was identified in 34 patients (9.3%), mainly Streptococcus pneumoniae (24 patients) followed by Streptococcus pyogenes (7 patients). The most frequent S. pneumoniae serotype was 19A (6 patients) and 3 vaccine failures were observed. The mean annual incidence rate was 14.3 cases per 100,000 children under 15 years of age (7.0 for PE- and 7.3 for PE+). No significant changes were observed in incidence over time, but noticeable differences in incidence were observed in different health departments.Conclusions: We have not found temporal variations in incidence of parapneumonic effusion despite the implementation of the 13-valent pneumococcal conjugate vaccine. The unexplained disparity in incidence between close departments is noteworthy.& COPY; 2022 Sociedad Espan & SIM;ola de Enfermedades Infecciosas y Microbiologi & PRIME;a Cli & PRIME;nica. Published by Elsevier Espan & SIM;a, S.L.U. All rights reserved.
Dados da publicação
- ISSN/ISSNe:
- 0213-005X, 1578-1852
- Tipo:
- Article
- Páginas:
- 414-419
- PubMed:
- 35985928
Enfermedades Infecciosas y Microbiologia Clinica Ediciones Doyma, S.L.
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 2
Documentos
- Não há documentos
Filiações
Keywords
- Pleural effusion; Pleural empyema; Bacterial pneumonia; Epidemiology; Pneumococcal vaccines
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Citar a publicação
Moral L,Toral T,Marco N,Clavijo A,Canals F,Fornies MJ,Gonzalez MC,Moral J,Marquez M,Lucas R,Caballero M,Huertas AM,Garcia B,Belda M. Epidemiology of pediatric parapneumonic pleural effusion during 13-valent pneumococcal conjugate vaccine implementation. Enfermedades Infecciosas y Microbiologia Clinica. 2023. 41. (7):p. 414-419. IF:2,500. (4).
