Portal de investigação
Long-Term Outcomes After Edge-to-Edge Repair of Secondary Mitral Regurgitation: 5-Year Results From the EuroSMR Registry
Autores da FMUP
Participantes de fora da FMUP
- Stocker T.J.
- Stolz L.
- Karam N.
- Kalbacher D.
- Koell B.
- Trenkwalder T.
- Xhepa E.
- Adamo M.
- Spieker M.
- Horn P.
- Butter C.
- Weckbach L.T.
- Novotny J.
- Melica B.
- Giannini C.
- von Bardeleben R.S.
- Pfister R.
- Praz F.
- Lurz P.
- Rudolph V.
- Metra M.
- Hausleiter J.
- Doldi P.
- Näbauer M.
- Massberg S.
- Popescu A.
- Ruf T.
- Iliadis C.
- Baldus S.
- Besler C.
- Kister T.
- Kresoja K.
- Thiele H.
- Ludwig S.
- Pauschinger C.
- Schofer N.
- Neuss M.
- Joner M.
- Omran H.
- Fortmeier V.
- Gerçek M.
- Zweck E.
- Kassar M.
- Windecker S.
- Puscas T.
- Lupi L.
- Pancaldi E.
- Tomasoni D.
- Petronio A.
Unidades de investigação
Abstract
Background: Mitral valve transcatheter edge-to-edge repair (M-TEER) reduces secondary mitral regurgitation (MR) in heart failure and impacts survival in selected patients as demonstrated in the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial. However, long-term outcome data after M-TEER under real-world conditions are lacking. Objectives: This study sought to assess long-term efficacy and survival after M-TEER in a large real-world registry. Methods: We analyzed patients with significant secondary MR undergoing M-TEER from the EuroSMR (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation) registry. Long-term MR reduction, functional outcomes, survival rate, and predictors for all-cause mortality were assessed. Results: In this study, 1,628 patients undergoing M-TEER (mean age 73.8 years, mean EuroSCORE II [European System for Cardiac Operative Risk Evaluation II] 6.9%, 86.6% NYHA functional class =III) with available long-term data were included. Five-year survival was 35.0%. Long-term MR reduction (MR grade =2+: baseline 4.1%, discharge 92.2%, 5-year follow-up 85.5%; P < 0.001) and functional improvement (NYHA =II: baseline 13.4%, 5-year follow-up 60.1%; P < 0.001) was observed. The degree of residual MR was associated with 5-year survival (residual MR grade =1+: 38.6%; 2+: 30.5%; =3+: 22.6%; P < 0.001). Independent predictors for 5-year all-cause mortality post–M-TEER included age, renal function, residual MR, NYHA functional class, left ventricular ejection-fraction, and COAPT trial eligibility (P < 0.01 for all). Conclusions: This extensive multicenter registry underscores the long-term efficacy of M-TEER in real-world clinical practice and identifies predictors for long-term survival. These findings contribute valuable insights for optimizing patient selection in routine clinical interventions. © 2024 The Authors
Dados da publicação
- ISSN/ISSNe:
- 1876-7605, 1936-8798
- Tipo:
- Article
- Páginas:
- 2543-2554
- Link para outro recurso:
- www.scopus.com
JACC-CARDIOVASCULAR INTERVENTIONS Elsevier Inc.
Citações Recebidas na Scopus: 1
Documentos
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Filiações
Keywords
- Aged; Aged, 80 and over; Cardiac Catheterization; Europe; Female; Functional Status; Heart Valve Prosthesis Implantation; Humans; Male; Middle Aged; Mitral Valve; Mitral Valve Insufficiency; Recovery of Function; Registries; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Ventricular Function, Left; adverse event; aged; clinical trial; convalescence; devices; diagnostic imaging; Europe; female; functional status; heart catheterization; heart left ventricle function; heart valve replacement; human; male; middle aged; mitral valve; mitral valve regurgitation; mortality; multicenter study; pathophysiology; register; risk assessment; risk factor; surgery; time factor; treatment outcome; very elderly
Proyectos asociados
Impacto dos acessos femorais guiados por ecografia vs fluoroscopia nas complicações vasculares associadas à implantação de válvula aórtica percutânea
Investigador Principal: Francisco Pedro Morais Dias de Almeida Sampaio
Estudo Clínico Académico . 2021
Citar a publicação
Stocker TJ,Stolz L,Karam N,Kalbacher D,Koell B,Trenkwalder T,Xhepa E,Adamo M,Spieker M,Horn P,Butter C,Weckbach LT,Novotny J,Melica B,Giannini C,von RS,Pfister R,Praz F,Lurz P,Rudolph V,Metra M,Hausleiter J,Doldi P,Näbauer M,Massberg S,Popescu A,Ruf T,Iliadis C,Baldus S,Besler C,Kister T,Kresoja K,Thiele H,Ludwig S,Pauschinger C,Schofer N,Neuss M,Joner M,Omran H,Fortmeier V,Gerçek M,Zweck E,Kassar M,Windecker S,Puscas T,Lupi L,Pancaldi E,Tomasoni D,Petronio A,Sampaio F. Long-Term Outcomes After Edge-to-Edge Repair of Secondary Mitral Regurgitation: 5-Year Results From the EuroSMR Registry. JACC Cardiovasc. Interventions. 2024. 17. (21):p. 2543-2554. IF:11,300. (1).
