Effects of Bariatric Surgery on Sarcopenic Obesity Outcomes: A One-Year Prospective Study in Middle-Aged Women

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Ilda Susana Oliveira Pinto E Ferreira Rodrigues

    Autor

  • Paula Isabel Marques Simões De Freitas

    Autor

Participantes de fora da FMUP

  • Rodrigues, Pietra S.
  • Mendonca, Fernando M.
  • Neves, Joao S.
  • Luis, Carla
  • Moreno, Telma
  • Festas, Diana
  • Pedro, Jorge
  • Varela, Ana
  • Fernandes, Ana
  • Costa, Eduardo L.
  • CRIO Grp

Unidades de investigação

Abstract

Introduction Sarcopenic obesity (SO) is characterised by the confluence of muscle deterioration and high adiposity. When non-surgical interventions prove insufficient, bariatric surgery (BS) becomes the primary approach. This study aimed to address BS effects on SO outcomes 1 year post-surgery among middle-aged women, also considering physical exercise's impact. Methods Prospective single-centre study of 140 patients who underwent Roux-en-Y gastric bypass or sleeve gastrectomy between November 2019 and December 2022. Participants were categorised into tertiles according to SO's diagnosis and severity (group 1-patients with the most severe SO; group 2-intermediate; group 3-the least severe or without SO), calculated considering the consensus issued by ESPEN and EASO in 2022. Evaluations of clinical and biochemical parameters were conducted before and 12 months after BS, and the variation was used for comparative purposes. Body composition was assessed using bone density scans. Linear regression analysis accounted for both surgery type and baseline body mass index (BMI). Results Before BS, SO prevalence in the overall sample was 89.3%, decreasing to 2.9% after BS. Group 1 had more body fat mass (56.9 vs 54.8 vs 50.7 kg, p < 0.001), total, trunk and leg fat at baseline and a significantly lower total skeletal muscle mass (47.2 vs 49.4 vs 51.8 kg, p < 0.001). One year post-BS, group 1 presented more weight loss (- 39.+/- PLUSMN; 11.4 kg, p = 0.031), BMI reduction (- 15.9 +/- 4.6 kg/m(2), p = 0.005) and lost more fat mass (- 32.6 vs - 30.5 vs - 27.9 kg, p = 0.005), but not total skeletal muscle mass (- 5.8 vs - 5.9 vs - 6.8 kg, p = 0.130). Remission rates for comorbidities were substantial among all groups, but more marked among patients within group 1 (type 2 diabetes mellitus 75%, hypertension 47.1% and dyslipidemia 52.8%). Engagement in physical exercise of any kind has increased post-BS (33.1% vs 79.1%). Conclusion Despite concerns about malabsorptive mechanisms potentially worsening muscle loss, patients with the most severe SO undergoing BS lost more fat mass while experiencing the smallest reduction in total skeletal muscle mass. Remission rates for comorbidities following BS were notable among all groups.

Dados da publicação

ISSN/ISSNe:
0960-8923, 1708-0428

Obesity Surgery  Springer New York

Tipo:
Article
Páginas:
1674-1683
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 1

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Keywords

  • Bariatric surgery; Sarcopenic obesity; Metabolic outcomes; Muscle mass; Weight loss; Physical exercise

Proyectos asociados

Metabolic syndrome is a main determinant of quality of life after metabolic surgery

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Estudo Clínico Académico (Hepatic Steatosis) . 2023

Obesity and Cancer: the profile of a population who underwent bariatric surgery

Investigador Principal: Paula Isabel Marques Simões de Freitas

Estudo Clínico Académico . 2021

The role of gut microbiota-host interaction in obesity and metabolic disturbances

Investigador Principal: Paula Isabel Marques Simões de Freitas

Estudo Clínico Académico . 2020

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