Portal de investigação
Effects of Bariatric Surgery on Sarcopenic Obesity Outcomes: A One-Year Prospective Study in Middle-Aged Women
Autores da FMUP
Participantes de fora da FMUP
- Rodrigues, Pietra S.
- Mendonca, Fernando M.
- Neves, Joao S.
- Luis, Carla
- Moreno, Telma
- Festas, Diana
- Pedro, Jorge
- Varela, Ana
- Fernandes, Ana
- Costa, Eduardo L.
- CRIO Grp
Unidades de investigação
Abstract
Introduction Sarcopenic obesity (SO) is characterised by the confluence of muscle deterioration and high adiposity. When non-surgical interventions prove insufficient, bariatric surgery (BS) becomes the primary approach. This study aimed to address BS effects on SO outcomes 1 year post-surgery among middle-aged women, also considering physical exercise's impact. Methods Prospective single-centre study of 140 patients who underwent Roux-en-Y gastric bypass or sleeve gastrectomy between November 2019 and December 2022. Participants were categorised into tertiles according to SO's diagnosis and severity (group 1-patients with the most severe SO; group 2-intermediate; group 3-the least severe or without SO), calculated considering the consensus issued by ESPEN and EASO in 2022. Evaluations of clinical and biochemical parameters were conducted before and 12 months after BS, and the variation was used for comparative purposes. Body composition was assessed using bone density scans. Linear regression analysis accounted for both surgery type and baseline body mass index (BMI). Results Before BS, SO prevalence in the overall sample was 89.3%, decreasing to 2.9% after BS. Group 1 had more body fat mass (56.9 vs 54.8 vs 50.7 kg, p < 0.001), total, trunk and leg fat at baseline and a significantly lower total skeletal muscle mass (47.2 vs 49.4 vs 51.8 kg, p < 0.001). One year post-BS, group 1 presented more weight loss (- 39.+/- PLUSMN; 11.4 kg, p = 0.031), BMI reduction (- 15.9 +/- 4.6 kg/m(2), p = 0.005) and lost more fat mass (- 32.6 vs - 30.5 vs - 27.9 kg, p = 0.005), but not total skeletal muscle mass (- 5.8 vs - 5.9 vs - 6.8 kg, p = 0.130). Remission rates for comorbidities were substantial among all groups, but more marked among patients within group 1 (type 2 diabetes mellitus 75%, hypertension 47.1% and dyslipidemia 52.8%). Engagement in physical exercise of any kind has increased post-BS (33.1% vs 79.1%). Conclusion Despite concerns about malabsorptive mechanisms potentially worsening muscle loss, patients with the most severe SO undergoing BS lost more fat mass while experiencing the smallest reduction in total skeletal muscle mass. Remission rates for comorbidities following BS were notable among all groups.
Dados da publicação
- ISSN/ISSNe:
- 0960-8923, 1708-0428
- Tipo:
- Article
- Páginas:
- 1674-1683
- Link para outro recurso:
- www.scopus.com
Obesity Surgery Springer New York
Citações Recebidas na Web of Science: 1
Documentos
- Não há documentos
Filiações
Keywords
- Bariatric surgery; Sarcopenic obesity; Metabolic outcomes; Muscle mass; Weight loss; Physical exercise
Campos de estudo
Proyectos asociados
Metabolic syndrome is a main determinant of quality of life after metabolic surgery
Investigador Principal: Paula Isabel Marques Simões de Freitas
Estudo Clínico Académico (Metabolic syndrome) . 2023
The impact of integrase inhibitors on the development of hepatic steatosis and fibrosis in HIV-monoinfected patients
Investigador Principal: Paula Isabel Marques Simões de Freitas
Estudo Clínico Académico (Hepatic Steatosis) . 2023
Obesity and Cancer: the profile of a population who underwent bariatric surgery
Investigador Principal: Paula Isabel Marques Simões de Freitas
Estudo Clínico Académico . 2021
The role of gut microbiota-host interaction in obesity and metabolic disturbances
Investigador Principal: Paula Isabel Marques Simões de Freitas
Estudo Clínico Académico . 2020
Citar a publicação
Rodrigues PS,Mendonca FM,Neves JS,Luis C,Rodrigues I,Moreno T,Festas D,Pedro J,Varela A,Fernandes A,Costa EL,Freitas P,CRIO GRP. Effects of Bariatric Surgery on Sarcopenic Obesity Outcomes: A One-Year Prospective Study in Middle-Aged Women. Obes. Surg. 2024. 34. (5):p. 1674-1683. IF:2,900. (2).
