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Supplemental Iron and Recombinant Erythropoietin for Anemia in Infants Born Very Preterm: A Survey of Clinical Practice in Europe

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Henrique Soares

    Autor

Participantes de fora da FMUP

  • Reibel-Georgi, Nora J.
  • Scrivens, Alexandra
  • Heeger, Lisanne E.
  • Lopriore, Enrico
  • New, V, Helen
  • Deschmann, Emoeuroke
  • Stanworth, Simon J.
  • Carrascosa, Marta Aguar
  • Braekke, Kristin
  • Cardona, Francesco
  • Cools, Filip
  • Farrugia, Ryan
  • Ghirardello, Stefano
  • Krivec, Jana Lozar
  • Matasova, Katarina
  • Muehlbacher, Tobias
  • Sankilampi, Ulla
  • Szabo, Miklos
  • Szczapa, Tomasz
  • Zaharie, Gabriela
  • Christoph, Charles
  • Fustolo-Gunnink, Suzanne
  • Dame, Christof

Unidades de investigação

Abstract

Objectives To survey practices of iron and recombinant human erythropoietin (rhEpo) administration to infants born preterm across Europe. Study design Over a 3-month period, we conducted an online survey in 597 neonatal intensive care units (NICUs) of 18 European countries treating infants born with a gestational age of <32 weeks. Results We included 343 NICUs (response rate 56.3%) in the survey. Almost all NICUs (97.7%) routinely supplement enteral iron, and 74.3% of respondents to all infants born <32 weeks of gestation. We found that 65.3% of NICUs routinely evaluate erythropoiesis and iron parameters beyond day 28 after birth. Most NICUs initiate iron supplementation at postnatal age of 2 weeks and stop after 6 months (34.3%) or 12 months (34.3%). Routine use of rhEpo was reported in 22.2% of NICUs, and in individual cases in 6.9%. RhEpo was mostly administered subcutaneously (70.1%) and most frequently at a dose of 250 U/kg 3 times a week (44.3%), but the dose varied greatly between centers. (44.3%), greatly Conclusions This survey highlights wide heterogeneity in evaluating erythropoietic activity and iron deficiency in infants born preterm. Variation in iron supplementation during infancy likely reflects an inadequate evidence base. Current evidence on the efficacy and safety profile of rhEpo is only poorly translated into clinical practice. This survey demonstrates a need for standards to optimize patient blood management in anemia of prematurity. (J Pediatr 2025;276:114302).

Dados da publicação

ISSN/ISSNe:
0022-3476, 1097-6833

Journal of Pediatrics  Mosby Inc.

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Scopus: 1

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Keywords

  • BIRTH-WEIGHT INFANTS; NECROTIZING ENTEROCOLITIS; TRANSFUSION; NEUROPROTECTION; OUTCOMES; TRIAL; DEFICIENCY

Campos de estudo

Proyectos asociados

Práticas Atuais de Reanimação Neonatal nas Salas de Partos em Portugal: Um Estudo Transversal

Investigador Principal: Henrique Soares

Estudo Clínico Académico (Reanimação Neonatal) . 2023

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