Spleen-Restricted Posttransplant Lymphoproliferative Disorder in the First Year After Kidney Transplant - A Case Report

Autores da FMUP

• Susana Maria Gouveia Fernandes

  Autor

• Inês Passos E Castro Neto Ferreira

  Autor

• Angela Maria Veloso Guimarães Carneiro

  Autor

Participantes de fora da FMUP

• Rodrigues, AC
• Bustorff, M
• Nunes, AT
• Salome, I.
• Rocha, A
• Sampaio, SN

Unidades de investigação

• Cirurgia e Fisiologia

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Patologia

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Posttransplant lymphoproliferative disorders (PTLDs) are a feared complication after transplant. They are mostly of B cell origin and are frequently Epstein-Barr virus (EBV)-positive, particu-larly in early onset PTLD. Later on, non-B and EBV-negative PTLD are increasingly reported. EBV seronegative receptors (particularly when paired with an EBV seropositive donor) together with the net degree of immunosuppression-a concept often difficult to quantify-are the most consistently described risk factors for the development of PTLD. Conversely, its association with a particular immunosuppressive agent or other virus, namely cytomegalovirus (CMV) infec-tion or disease, has been inconsistently reported. We present a challenging case where an EBV negative monomorphic peripheric T-cell lymphoma was diagnosed in the first year after kidney in a with a recent of CMV disease from a resistant strain.

Keywords

• T-CELL LYMPHOMA; EPIDEMIOLOGY; VIRUSES