SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis

Data de publicação:

Autores da FMUP

  • Luís Filipe Gomes Malheiro

    Autor

  • Salomé Soares Pinho

    Autor

Participantes de fora da FMUP

  • Alves, Ines
  • Vicente, Manuel Machado
  • Gaifem, Joana
  • Fernandes, Angela
  • Dias, Ana Mendes
  • Rodrigues, Claudia Sousa
  • Oliveira, Jose Carlos
  • Seixas, Nair
  • Abreu, Miguel Araujo
  • Sarmento e Castro, Rui

Unidades de investigação

Abstract

COVID-19 is a highly selective disease in which SARS-CoV-2 infection can result in different clinical manifestations ranging from asymptomatic/mild to severe disease that requires hospitalization. In this study, we demonstrated that SARS-CoV-2 infection results in a glycosylation reprogramming of circulating lymphocytes at diagnosis. We identified a specific glycosignature of T cells, defined upon SARS-CoV-2 infection and apparently triggered by a serological factor. This specific glycan switch of T cells is detected at diagnosis being more pronounced in asymptomatic patients. We further demonstrated that asymptomatic patients display an increased expression of a viral-sensing receptor through the upregulation of DC-SIGN in monocytes. We showed that higher levels of DC-SIGN in monocytes at diagnosis correlates with better COVID-19 prognosis. This new evidence pave the way to the identification of a novel glycan-based response in T cells that may confer protection against SARS-CoV-2 infection in asymptomatic patients, highlighting a novel prognostic biomarker and potential therapeutic target.

Dados da publicação

ISSN/ISSNe:
1550-6606, 0022-1767

Journal of Immunology  American Association of Immunologists

Tipo:
Article
Páginas:
1591-1598
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 7

Citações Recebidas na Scopus: 7

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Keywords

  • GLYCOSYLATION; SUSCEPTIBILITY; GLYCOPROTEIN; AUTOIMMUNITY; PROTEIN; VIRUS

Proyectos asociados

The impact of SARS-CoV-2 viral load on the mortality of hospitalized patients. A retrospective analysis

Investigador Principal: Luís Filipe Gomes Malheiro

Estudo Clínico Académico (SARS-CoV-2) . 2021

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