Portal de investigação
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Alves, Ines
- Vicente, Manuel Machado
- Gaifem, Joana
- Fernandes, Angela
- Dias, Ana Mendes
- Rodrigues, Claudia Sousa
- Oliveira, Jose Carlos
- Seixas, Nair
- Abreu, Miguel Araujo
- Sarmento e Castro, Rui
Unidades de investigação
Abstract
COVID-19 is a highly selective disease in which SARS-CoV-2 infection can result in different clinical manifestations ranging from asymptomatic/mild to severe disease that requires hospitalization. In this study, we demonstrated that SARS-CoV-2 infection results in a glycosylation reprogramming of circulating lymphocytes at diagnosis. We identified a specific glycosignature of T cells, defined upon SARS-CoV-2 infection and apparently triggered by a serological factor. This specific glycan switch of T cells is detected at diagnosis being more pronounced in asymptomatic patients. We further demonstrated that asymptomatic patients display an increased expression of a viral-sensing receptor through the upregulation of DC-SIGN in monocytes. We showed that higher levels of DC-SIGN in monocytes at diagnosis correlates with better COVID-19 prognosis. This new evidence pave the way to the identification of a novel glycan-based response in T cells that may confer protection against SARS-CoV-2 infection in asymptomatic patients, highlighting a novel prognostic biomarker and potential therapeutic target.
Dados da publicação
- ISSN/ISSNe:
- 1550-6606, 0022-1767
- Tipo:
- Article
- Páginas:
- 1591-1598
- Link para outro recurso:
- www.scopus.com
Journal of Immunology American Association of Immunologists
Citações Recebidas na Web of Science: 7
Citações Recebidas na Scopus: 7
Documentos
- Não há documentos
Filiações
Keywords
- GLYCOSYLATION; SUSCEPTIBILITY; GLYCOPROTEIN; AUTOIMMUNITY; PROTEIN; VIRUS
Proyectos asociados
The impact of SARS-CoV-2 viral load on the mortality of hospitalized patients. A retrospective analysis
Investigador Principal: Luís Filipe Gomes Malheiro
Estudo Clínico Académico (SARS-CoV-2) . 2021
Citar a publicação
Alves I,Vicente MM,Gaifem J,Fernandes A,Dias AM,Rodrigues CS,Oliveira JC,Seixas N,Malheiro L,Abreu MA,Sarmento e Castro R,Pinho SS. SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis. J. Immunol. 2021. 207. (6):p. 1591-1598. IF:5,426. (2).
