Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir: A case study

Data de publicação:

Autores da FMUP

  • Luís Filipe Gomes Malheiro

    Autor

Participantes de fora da FMUP

  • Matos F.B.
  • Mbanze D.
  • Gomes P.
  • Figueiredo C.
  • Coutinho D.
  • Nunes S.
  • Azevedo C.
  • Fragoso J.
  • Teixeira T.

Unidades de investigação

Abstract

Resistance to antiretroviral therapy is an increasing challenge in the management of HIV. We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance. © The Author(s) 2024.

Dados da publicação

ISSN/ISSNe:
0956-4624, 1758-1052

INTERNATIONAL JOURNAL OF STD & AIDS  SAGE Publications Ltd

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

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Keywords

  • Adult; Anti-HIV Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Middle Aged; Morpholines; Organophosphates; Piperazines; Treatment Outcome; Viral Load; anti human immunodeficiency virus agent; fostemsavir; morpholine derivative; organophosphate; piperazine derivative; adult; case report; combination drug therapy; drug effect; drug therapy; female; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; middle aged; multidrug resistance; treatment outcome; virus load

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Side effects of latent tuberculosis treatment with isoniazid in people living with HIV: a case-control study in a resource-rich setting

Investigador Principal: Luís Filipe Gomes Malheiro

Estudo Clínico Académico (HIV) . 2023

The impact of SARS-CoV-2 viral load on the mortality of hospitalized patients. A retrospective analysis

Investigador Principal: Luís Filipe Gomes Malheiro

Estudo Clínico Académico (SARS-CoV-2) . 2021

Secondary Organising Pneumonia among COVID-19 patients: a retrospective case control study

Investigador Principal: Luís Filipe Gomes Malheiro

Estudo Clínico Académico (Pneumonia) . 2022

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