Immune checkpoint inhibitor-induced endocrinopathies: a possible indicator of improved survival

Data de publicação:

Autores da FMUP

  • Marta Borges Canha

    Autor

Participantes de fora da FMUP

  • Ornelas, M
  • Gouveia, P
  • Ferreira, M
  • Resende, E
  • Sá, M
  • Abreu, S

Unidades de investigação

Abstract

Objective: To evaluate the association between the patients' characteristics and the development of endocrine toxicity and to assess the association between endocrine-related adverse effects (ERAE) development and mortality. Subjects and methods: A retrospective observational study was conducted in 98 patients submitted to immunotherapy in our centre since its introduction in 2015 until March 2021. We excluded patients for which data regarding the corticotroph axis evaluation was missing. We used linear and logistic regression models to address our aims. Results: We observed a significant negative association between ERAE development and death (OR 0.32; p = 0.028). We detected no associations between ERAE and the following characteristics: age at immune checkpoint inhibitors (ICI) initiation, sex, diabetes mellitus, medical history, immunotherapy duration and ICI type. Conclusion: The development of an ERAE may be associated with a better overall survival rate in advanced oncologic disease, supporting the role of an unleashed immune system response to malignant cells.

Dados da publicação

ISSN/ISSNe:
2359-3997, 2359-4292

ARCHIVES OF ENDOCRINOLOGY METABOLISM  Segmento Farma Editores

Tipo:
Article
Páginas:
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Keywords

  • Immune checkpoint inhibitors; immunotherapy; endocrine system diseases; drug-related side effects and adverse reactions

Proyectos asociados

Relation between weight gain during pregnancy and postpartum reclassification in gestational diabetes

Investigador Principal: Marta Borges Canha

Estudo Clínico Académico (Gestational Diabetes) . 2023

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