Portal de investigação
Sleep Duration and Stress Level in the Risk of Gastric Cancer: A Pooled Analysis of Case-Control Studies in the Stomach Cancer Pooling (StoP) Project
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Collatuzzo, G
- Pelucchi, C
- Negri, E
- Kogevinas, M
- Huerta, JM
- Vioque, J
- de la Hera, MG
- Tsugane, S
- Hamada, GS
- Hidaka, A
- Zhang, ZF
- Camargo, MC
- Curado, MP
- La Vecchia, C
- Boffetta, P
Unidades de investigação
Abstract
The association between sleep and stress and cancer is underinvestigated. We evaluated these factors in association with gastric cancer (GC). Five case-control studies from the Stomach Cancer Pooling (StoP) Project were included. We calculated the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for sleep duration and stress level in association with GC through multiple logistic regression models adjusted for several lifestyle factors. The analysis included 1293 cases and 4439 controls, 215 cardia and 919 noncardia GC, and 353 diffuse and 619 intestinal types. Sleep duration of =9 h was associated with GC (OR =1.57, 95% CI = 1.23-2.00) compared to 8 h. This was confirmed when stratifying by subsite (noncardia OR = 1.59, 95% CI = 1.22-2.08, and cardia OR = 1.63, 95% CI = 0.97-2.72) and histological type (diffuse OR = 1.65, 95% CI = 1.14-2.40 and intestinal OR = 1.24, 95% CI = 0.91-1.67). Stress was associated with GC (OR = 1.33, 95% CI = 1.18-1.50, continuous). This relationship was selectively related to noncardia GC (OR = 1.28, 95% 1.12-1.46, continuous). The risk of diffuse (OR = 1.32, 95% CI = 1.11-1.58) and intestinal type (OR = 1.23, 95% CI = 1.07-1.42) were higher when stress was reported. Results for the association between increasing level of stress and GC were heterogeneous by smoking and socioeconomic status (p for heterogeneity = 0.02 and <0.001, respectively). In conclusion, long sleep duration (=9 h) was associated with GC and its subtype categories. Stress linearly increased the risk of GC and was related to noncardia GC.
Dados da publicação
- ISSN/ISSNe:
- 2072-6694, 2072-6694
- Tipo:
- Article
- Páginas:
- 4319-
- Link para outro recurso:
- www.scopus.com
Cancers Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Scopus: 4
Documentos
- Não há documentos
Filiações
Keywords
- gastric cancer; sleep; sleep duration; stress; circadian rhythm; lifestyle; cardia; noncardia
Financiamento
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Citar a publicação
Collatuzzo G,Pelucchi C,Negri E,Kogevinas M,Huerta JM,Vioque J,de la Hera MG,Tsugane S,Hamada GS,Hidaka A,Zhang ZF,Camargo MC,Curado MP,Lunet N,La Vecchia C,Boffetta P. Sleep Duration and Stress Level in the Risk of Gastric Cancer: A Pooled Analysis of Case-Control Studies in the Stomach Cancer Pooling (StoP) Project. Cancers. 2023. 15. (17):p. 4319-4319. IF:5,200. (2).
