Systematic Review of Platelet-Rich Plasma for Low Back Pain

Data de publicação:

Autores da FMUP

  • Daniel Humberto Pozza

    Autor

Participantes de fora da FMUP

  • Machado, ES
  • Soares, FP
  • de Abreu, EV
  • de Souza, TAD
  • Meves, R
  • Grohs, H
  • Ambach, MA
  • Navani, A
  • de Castro, RB
  • Caldas, JMP

Unidades de investigação

Abstract

Background: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine. The present study aims to evaluate the efficacy of PRP injections in managing low back pain. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, a registered at PROSPERO Systematic Reviews Platform, under number CRD42021268491. The PubMed, Web of Science, and Scopus databases were searched to identify relevant articles, along with hand searching to identify gray literature articles, with no language restrictions. Randomized clinical trials (RCTs), nonrandomized trials (NRTs), and case series (CSs) with more than 10 patients were considered eligible. The quality assessment and the risk of bias of the randomized clinical trials were evaluated using the RoB II tool. An evaluation of the description of the preparation methods was performed using an adapted version of the MIBO checklist. Results: An electronic database search resulted in 2324 articles, and after the exclusion of noneligible articles, 13 RCTs and 27 NRTs or CSs were analyzed. Of the 13 RCTs, 11 found favorable results in comparison to the control group in pain and disability, one showed no superiority to the control group, and one was discontinued because of the lack of therapeutic effect at eight-week evaluation. Description of the PRP preparation techniques were found in almost all papers. The overall risk of bias was considered high in 2 papers and low in 11. An adapted MIBO checklist showed a 72.7% compliance rate in the selected areas. Conclusions: In this systematic review, we analyzed articles from English, Spanish and Russian language, from large databases and grey literature. PRP was in general an effective and safe treatment for degenerative LPB. Positive results were found in almost studies, a small number of adverse events were related, the risk of bias of the RCTs was low. Based on the evaluation of the included studies, we graded as level II the quality of the evidence supporting the use of PRP in LBP. Large-scale, multicenter RCTs are still needed to confirm these findings.

Dados da publicação

ISSN/ISSNe:
2227-9059, 2227-9059

Biomedicines  MDPI AG

Tipo:
Review
Páginas:
2404-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Scopus: 10

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Keywords

  • platelet-rich plasma; low back pain; discogenic pain; facet pain; orthobiologics; regenerative medicine; spinal injection; epidural injection

Proyectos asociados

Resultados de um Protocolo QST em voluntários saudáveis e em pacientes com dor crónica: um ensaio clínico controlado

Investigador Principal: Daniel Humberto Pozza

Ensaio Clínico Académico (Dor Crónica) . 2023

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