Glucagon-Like Peptide-1 Receptor Agonists Across the Spectrum of Heart Failure

Autores da FMUP
Participantes de fora da FMUP
- Sharma, A
- Butler, J
- Packer, M
- Zannad, F
Unidades de investigação
Abstract
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been used to reduce body weight in overweight or people with obesity and to improve glycemic control and cardiovascular outcomes among people with type 2 diabetes (T2D) and a high cardiovascular risk. However, the effects of GLP-1 RAs may be modified by the presence of heart failure (HF). In this review, we summarize the evidence for the use of GLP-1 RA across a patient's risk with a particular focus on HF. After a careful review of the literature, we challenge the current views about the use of GLP-1 RAs and suggest performing active HF screening (with directed clinical history, physical examination, an echocardiogram, and natriuretic peptides) before initiating a GLP-1 RA. After HF screening, we suggest GLP-1 RA treatment decisions as follows: (1) in people with T2D without HF, GLP-1 RAs should be used for reducing the risk of myocardial infarction and stroke, with a possible effect to reduce the risk of HF hospitalizations; (2) in patients with HF and preserved ejection fraction, GLP-1 RAs do not reduce HF hospitalizations but may reduce atherosclerotic events, and their use may be considered in an individualized manner; and (3) in patients with HF and reduced ejection fraction, the use of GLP-1 RAs warrants caution due to potential risk of worsening HF events and arrhythmias, pending risk-benefit data from further studies.
© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Dados da publicação
- ISSN/ISSNe:
- 0021-972X, 1945-7197
- Tipo:
- Review
- Páginas:
- 4-9
- Link para outro recurso:
- www.scopus.com
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Endocrine Society
Citações Recebidas na Web of Science: 2
Citações Recebidas na Scopus: 17
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Keywords
- glucagon-like peptide-1 receptor agonists; heart failure; risk modification
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Citar a publicação
Ferreira J,Sharma A,Butler J,Packer M,Zannad F,Vasques F,Leite A,Neves J. Glucagon-Like Peptide-1 Receptor Agonists Across the Spectrum of Heart Failure. J. Clin. Endocrinol. Metab. 2023. 109(1):p. 4-9. IF:5,800. (1).